中文版 | English
Title

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Author
Corresponding AuthorLiu, Yingxia; Jiang, Chengyu; Liu, Lei
Publication Years
2020-02-09
DOI
Source Title
ISSN
1674-7305
EISSN
1869-1889
Volume63Issue:3Pages:364-374
Abstract
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.
Keywords
URL[Source Record]
Indexed By
Language
English
Funding Project
China Postdoctoral Science Foundation[2019T120147]
WOS Research Area
Life Sciences & Biomedicine - Other Topics
WOS Subject
Biology
WOS Accession No
WOS:000518376300004
Publisher
Important Publications
ESI Highly Cited Papers ; ESI Hot Papers ; ESI Hot Papers ; ESI Hot Papers ; ESI Hot Papers ; ESI Hot Papers
SUSTech Authorship
First ; Corresponding
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:360
Document TypeJournal Article
Identifierhttps://kc.sustech.edu.cn/handle/2SGJ60CL/104583
DepartmentSouthern University of Science and Technology
Affiliation
1.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis,Shenzhen Peoples, Natl Clin Res Ctr Infect Dis,Hosp Affiliated 1, Shenzhen 518112, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
4.Chinese Acad Med Sci, Dept Biochem, Peking Union Med Coll, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
5.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
6.Peking Union Med Coll Hosp, Emergence Dept, Beijing 100731, Peoples R China
First Author AffilicationSouthern University of Science and Technology
Corresponding Author AffilicationSouthern University of Science and Technology
First Author's First AffilicationSouthern University of Science and Technology
Recommended Citation
GB/T 7714
Liu, Yingxia,Yang, Yang,Zhang, Cong,et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury[J]. SCIENCE CHINA: LIFE SCIENCES,2020,63(3):364-374.
APA
Liu, Yingxia.,Yang, Yang.,Zhang, Cong.,Huang, Fengming.,Wang, Fuxiang.,...&Liu, Lei.(2020).Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.SCIENCE CHINA: LIFE SCIENCES,63(3),364-374.
MLA
Liu, Yingxia,et al."Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury".SCIENCE CHINA: LIFE SCIENCES 63.3(2020):364-374.
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