Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhou，Zhuo1,2; Ren，Lili2,3; Zhang，Li4; Zhong，Jiaxin4,5; Xiao，Yan2; Jia，Zhilong6; Guo，Li2; Yang，Jing4,5; Wang，Chun4,5; Jiang，Shuai4; Yang，Donghong7; Zhang，Guoliang8; Li，Hongru9; Chen，Fuhui10; Xu，Yu7; Chen，Mingwei11; Gao，Zhancheng7; Yang，Jian2; Dong，Jie2; Liu，Bo2; Zhang，Xiannian12; Wang，Weidong6; He，Kunlun6; Jin，Qi2; Li，Mingkun2,4,13; Wang，Jianwei2,3

2020

10.1016/j.chom.2020.04.017

Cell Host & Microbe   Impact Factor & Quartile

1931-3128

1934-6069

Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.

Bronchoalveolar lavage fluid Chemokines Coronavirus COVID-19 Hypercytokinemia Innate immune response Interferon response Interferon-stimulated genes Metatranscriptomic sequencing SARS-CoV-2

SCI

English

NI Journal Papers ; NI论文 ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers

Others

National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China[2017ZX10204401][2018ZX10301401][2017ZX10103004][2018ZX10305409] ; Innovation Fund for Medical Sciences[2016-I2M-1-014] ; National Natural Science Foundation of China[31670169][31470267][31701155] ; National Key Research and Development Program of China[2017YFC0908403][2020YFA0707600] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2019PT310029] ; Strategic Priority CAS Project[XDB38000000]

Microbiology ; Parasitology ; Virology

Microbiology ; Parasitology ; Virology

WOS:000540760600009

CELL PRESS

2-s2.0-85084457061

Scopus

1.Biomedical Pioneering Innovation Center,Beijing Advanced Innovation Center for Genomics,Peking University Genome Editing Research Center,School of Life Sciences,Peking University,Beijing,100871,China
2.National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100730,China
3.Key Laboratory of Respiratory Disease Pathogenomics,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100730,China
4.Beijing Institute of Genomics,Chinese Academy of Sciences,and China National Center for Bioinformation,Beijing,100101,China
5.University of Chinese Academy of Sciences,Beijing,100049,China
6.Key Laboratory of Biomedical Engineering and Translational Medicine,Ministry of Industry and Information Technology,Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure,Chinese PLA General Hospital,Beijing,100853,China
7.Department of Respiratory and Critical Care Medicine,Peking University People's Hospital,Beijing,100044,China
8.National Clinical Research Center for Infectious Diseases,Guangdong Key Laboratory for Emerging Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,518112,China
9.Fujian Provincial Hospital,Fujian,350000,China
10.Department of respiratory,the Second Affiliated Hospital of Harbin Medical University,Harbin,150001,China
11.Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,710061,China
12.School of Basic Medical Sciences,Beijing Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,100069,China
13.Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming,650223,China

Zhou，Zhuo,Ren，Lili,Zhang，Li,et al. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients[J]. Cell Host & Microbe,2020,27(6):883-+.

Zhou，Zhuo.,Ren，Lili.,Zhang，Li.,Zhong，Jiaxin.,Xiao，Yan.,...&Wang，Jianwei.(2020).Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients.Cell Host & Microbe,27(6),883-+.

Zhou，Zhuo,et al."Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients".Cell Host & Microbe 27.6(2020):883-+.