中文版 | English
Title

Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice

Author
Corresponding AuthorJu,Bin
Publication Years
2022-12-01
DOI
Source Title
EISSN
1743-422X
Volume19Issue:1
Abstract
The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antibody responses against variants including Beta, Delta, Alpha, Iota, Kappa, and A.23.1. These data showed that a third booster dose of heterologous RBD vaccine especially after two doses of inactivated vaccines significantly enhanced the GMTs of nAbs against all SARS-CoV-2 variants we tested. In addition, the WT and variants all displayed good cross-immunogenicity and might be applied in the design of booster vaccines to induce broadly neutralizing antibodies.
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URL[Source Record]
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Language
English
SUSTech Authorship
Corresponding
WOS Accession No
WOS:000738608100001
ESI Research Field
MICROBIOLOGY
Scopus EID
2-s2.0-85122330427
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttps://kc.sustech.edu.cn/handle/2SGJ60CL/264241
DepartmentSchool of Medicine
南方科技大学第二附属医院
Affiliation
1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,Shenzhen,Guangdong Province,China
2.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,China
3.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong Province,China
4.Guangdong Key Laboratory for Anti-Infection Drug Quality Evaluation,Shenzhen,Guangdong Province,China
5.Institute of Biophysics,Chinese Academy of Sciences,Beijing,China
6.Guangzhou Laboratory,and Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,China
7.Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing,China
First Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Corresponding Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Recommended Citation
GB/T 7714
Song,Shuo,Zhou,Bing,Cheng,Lin,et al. Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice[J]. Virology Journal,2022,19(1).
APA
Song,Shuo.,Zhou,Bing.,Cheng,Lin.,Liu,Weilong.,Fan,Qing.,...&Zhang,Zheng.(2022).Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice.Virology Journal,19(1).
MLA
Song,Shuo,et al."Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice".Virology Journal 19.1(2022).
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