| Title | Indent Size Effects of Hydrogels at Micro-Meter Scale |
| Author | |
| Corresponding Author | Tang, Bin |
| Publication Years | 2018-11
|
| DOI | |
| Source Title | |
| ISSN | 2157-9083
|
| EISSN | 2157-9091
|
| Volume | 8Issue:11Pages:1617-1621 |
| Abstract | Extracellular matrix (ECM) stiffness can produce mechanical signals to cells and subsequently affect the behavior and function of the cells. Therefore, various hydrogels with similar properties to ECM (I) and controllable hardness are widely applied in various tissues engineering designs. The hydrogels can provide mechanical signals to control cell differentiation and promote cell proliferation directly. Currently, the studies of the mechanical properties of hydrogels are often on macroscopic scales, while the size of cells is different and often scales to the micron scales. In this study, we prepared the cylindrical AFM tips with different diameters for AFM nanoindentation to simulate the contact process between cells with different physical sizes and hydrogel matrix. The results discovered that the elastic modulus of hydrogels is highly dependent on the diameters of the indentation tips. Furthermore, it is found that the diameter/aperture ratio also has a significant effect on the dispersion of the measured elastic modulus. This result indicates that the cells with different sizes sense different ECM stiffness. On the basis of our results, it demonstrates that the pore size of hydrogels for tissue engineering is a vital factor to be considered to obtain a more consistent mechanical and biological results. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Shenzhen Science and Technology Innovation Committee[JCYJ20160517160827379]
|
| WOS Research Area | Cell Biology
|
| WOS Subject | Cell & Tissue Engineering
|
| WOS Accession No | WOS:000458828200013
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/27046 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 2.Univ Hong Kong, Dept Mech Engn, Hong Kong 999077, Peoples R China 3.Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen 518055, Peoples R China 4.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Wang, Kui,Pang, Xiangchao,Ge, Yongmei,et al. Indent Size Effects of Hydrogels at Micro-Meter Scale[J]. Journal of Biomaterials and Tissue Engineering,2018,8(11):1617-1621.
|
| APA |
Wang, Kui.,Pang, Xiangchao.,Ge, Yongmei.,Ma, Fenbo.,Shen, Xinyu.,...&Tang, Bin.(2018).Indent Size Effects of Hydrogels at Micro-Meter Scale.Journal of Biomaterials and Tissue Engineering,8(11),1617-1621.
|
| MLA |
Wang, Kui,et al."Indent Size Effects of Hydrogels at Micro-Meter Scale".Journal of Biomaterials and Tissue Engineering 8.11(2018):1617-1621.
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment