Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization

Han, Lu1; Lu, Xiong1,2; Liu, Kezhi1; Wang, Kefeng2; Fang, Liming3; Weng, Lu-Tao4; Zhang, Hongping5; Tang, Youhong6,7; Ren, Fuzeng8; Zhao, Cancan8; Sun, Guoxing4; Liang, Rui4; Li, Zongjin4

2017-03

10.1021/acsnano.6b05318

ACS Nano   Impact Factor & Quartile

1936-0851

1936-086X

Adhesive hydrogels are attractive biomaterials for various applications, such as electronic skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both adequate adhesiveness and excellent mechanical properties remains a challenge. Inspired by the adhesion mechanism of mussels, we used a two-step process to develop an adhesive and tough polydopamine-clay-polyacrylamide (PDA-clay-PAM) hydrogel. Dopamine was intercalated into clay nanosheets and limitedly oxidized between the layers, resulting in PDA-intercalated clay nanosheets containing free catechol groups. Acrylamide monomers were then added and in situ polymerized to form the hydrogel. Unlike previous single-use adhesive hydrogels, our hydrogel showed repeatable and durable adhesiveness. It adhered directly on human skin without causing an inflammatory response and was easily removed without causing damage. The adhesiveness of this hydrogel was attributed to the presence of enough free catechol groups in the hydrogel, which were created by controlling the oxidation process of the PDA in the confined nanolayers of clay. This mimicked the adhesion mechanism of the mussels, which maintain a high concentration of catechol groups in the confined nanospace of their byssal plaque. The hydrogel also displayed superior toughness, which resulted from nanoreinforcement by clay and PDA-induced cooperative interactions with the hydrogel networks. Moreover, the hydrogel favored cell attachment and proliferation, owning to the high cell affinity of PDA. Rat full-thickness skin defect experiments demonstrated that the hydrogel was an excellent dressing. This free-standing, adhesive, tough, and biocompatible hydrogel may be more convenient for surgical applications than adhesives that involve in situ gelation and extra agents.

mussel-inspired polydopamine nanoclay adhesive hydrogel tough hydrogel wound dressing

SCI ; EI

English

NI Journal Papers ; NI论文 ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers ; ESI Highly Cited Papers

Others

Fundamental Research Funds for the Central Universities[2682016CX075]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000398014900023

AMER CHEMICAL SOC

20171403517884

Adhesion ; Amines ; Biocompatibility ; Biomechanics ; Gelation ; Molluscs ; Nanocomposites ; Nanosheets ; Nanostructured materials ; Neurophysiology ; Phenols

Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Solid State Physics:933 ; Materials Science:951

Web of Science

1.Southwest Jiaotong Univ, Minist Educ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.Sichuan Univ, Natl Engn Res Ctr Biomat, Genome Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
3.South China Univ Technol China, Sch Mat Sci & Engn, Dept Polymer Sci & Engn, Guangzhou 510641, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Civil & Environm Engn, Dept Chem & Biomol Engn, Mat Characterisat & Preparat Facil, Hong Kong, Hong Kong, Peoples R China
5.Southwest Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomass Mat, Sch Mat Sci & Engn, Mianyang 621010, Peoples R China
6.Flinders Univ S Australia, Ctr NanoScale Sci & Technol, Adelaide, SA 5042, Australia
7.Flinders Univ S Australia, Sch Comp Sci Engn & Math, Adelaide, SA 5042, Australia
8.South Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China

Han, Lu,Lu, Xiong,Liu, Kezhi,et al. Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization[J]. ACS Nano,2017,11(3):2561-2574.

Han, Lu.,Lu, Xiong.,Liu, Kezhi.,Wang, Kefeng.,Fang, Liming.,...&Li, Zongjin.(2017).Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization.ACS Nano,11(3),2561-2574.

Han, Lu,et al."Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization".ACS Nano 11.3(2017):2561-2574.