中文版 | English
Title

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

Author
Corresponding AuthorQi,Jianxun; Gao,George F.; Wang,Peiyi; Qi,Jianxun; Gao,George F.; Wang,Peiyi
Publication Years
2022-02-17
DOI
Source Title
ISSN
0092-8674
EISSN
1097-4172
Volume185Issue:4Pages:630-640.e10
Abstract

The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2.

Keywords
URL[Source Record]
Indexed By
Language
English
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SUSTech Authorship
Corresponding
Funding Project
Chinese Academy of Sciences[XDB29010202] ; Chinese Academy of Sciences[XDB37030204]
WOS Research Area
Biochemistry & Molecular Biology ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No
WOS:000768265900006
Publisher
Scopus EID
2-s2.0-85123715877
Data Source
Scopus
Citation statistics
Cited Times [WOS]:61
Document TypeJournal Article
Identifierhttps://kc.sustech.edu.cn/handle/2SGJ60CL/327729
DepartmentDepartment of Biology
冷冻电镜中心
Affiliation
1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China
2.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China
3.University of Chinese Academy of Sciences,Beijing,100049,China
4.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
5.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China
6.Faculty of Health Sciences,University of Macau,Macau,999078,China
7.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China
8.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong
9.College of life Science,Shanxi University,Taiyuan,03006,China
10.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China
11.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China
12.University of Chinese Academy of Sciences,Beijing,100049,China
13.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
14.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China
15.Faculty of Health Sciences,University of Macau,Macau,999078,China
16.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China
17.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong
18.College of life Science,Shanxi University,Taiyuan,03006,China
Corresponding Author AffilicationDepartment of Biology
Recommended Citation
GB/T 7714
Han,Pengcheng,Li,Linjie,Liu,Sheng,et al. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2[J]. Cell,2022,185(4):630-640.e10.
APA
Han,Pengcheng.,Li,Linjie.,Liu,Sheng.,Wang,Qisheng.,Zhang,Di.,...&Wang,Peiyi.(2022).Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.Cell,185(4),630-640.e10.
MLA
Han,Pengcheng,et al."Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2".Cell 185.4(2022):630-640.e10.
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