南方科技大学知识苑(SUSTech KC): Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

Title	Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Author	Han，Pengcheng 1,2; Li，Linjie 1,3; Liu，Sheng4 ; Wang，Qisheng 5; Zhang，Di 1,6; Xu，Zepeng 1,6; Han，Pu 1; Li，Xiaomei 7; Peng，Qi 1; Su，Chao 8; Huang，Baihan 1; Li，Dedong 1; Zhang，Rong 1; Tian，Mingxiong 9; Fu，Lutang4 ; Gao，Yuanzhu4 ; Zhao，Xin 1; Liu，Kefang 1; Qi，Jianxun 1,3; Gao，George F.1,3; Wang，Peiyi4 ; Han，Pengcheng 10,11; Li，Linjie 10,12; Liu，Sheng 13 ; Wang，Qisheng 14; Zhang，Di 10,15; Xu，Zepeng 10,15; Han，Pu 10; Li，Xiaomei 16; Peng，Qi 10; Su，Chao 17; Huang，Baihan 10; Li，Dedong 10; Zhang，Rong 10; Tian，Mingxiong 18; Fu，Lutang13 ; Gao，Yuanzhu13 ; Zhao，Xin 10; Liu，Kefang 10; Qi，Jianxun 10,12; Gao，George F.10,12; Wang，Peiyi13
Corresponding Author	Qi，Jianxun; Gao，George F.; Wang，Peiyi; Qi，Jianxun; Gao，George F.; Wang，Peiyi
Publication Years	2022-02-17
DOI	10.1016/j.cell.2022.01.001
Source Title	Cell Impact Factor & Quartile
ISSN	0092-8674
EISSN	1097-4172
Volume	185 Issue:4Pages:630-640.e10
Abstract	The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2.
Keywords	Delta Hace2 Omicron Rbd Receptor-binding Domain Structure Variants Of Concern Vocs
URL	[Source Record]
Indexed By	SCI
Language	English
Important Publications	NI Journal Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers ; ESI Hot Papers ; ESI Highly Cited Papers
SUSTech Authorship	Corresponding
Funding Project	Chinese Academy of Sciences[XDB29010202] ; Chinese Academy of Sciences[XDB37030204]
WOS Research Area	Biochemistry & Molecular Biology ; Cell Biology
WOS Subject	Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No	WOS:000768265900006
Publisher	CELL PRESS
Scopus EID	2-s2.0-85123715877
Data Source	Scopus
Citation statistics	Cited Times [WOS]:61
Document Type	Journal Article
Identifier	https://kc.sustech.edu.cn/handle/2SGJ60CL/327729
Department	Department of Biology 冷冻电镜中心
Affiliation	1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China 2.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China 3.University of Chinese Academy of Sciences,Beijing,100049,China 4.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 5.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China 6.Faculty of Health Sciences,University of Macau,Macau,999078,China 7.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China 8.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong 9.College of life Science,Shanxi University,Taiyuan,03006,China 10.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China 11.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China 12.University of Chinese Academy of Sciences,Beijing,100049,China 13.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 14.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China 15.Faculty of Health Sciences,University of Macau,Macau,999078,China 16.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China 17.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong 18.College of life Science,Shanxi University,Taiyuan,03006,China
Corresponding Author Affilication	Department of Biology
Recommended Citation GB/T 7714	Han，Pengcheng,Li，Linjie,Liu，Sheng,et al. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2[J]. Cell,2022,185(4):630-640.e10.
APA	Han，Pengcheng.,Li，Linjie.,Liu，Sheng.,Wang，Qisheng.,Zhang，Di.,...&Wang，Peiyi.(2022).Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.Cell,185(4),630-640.e10.
MLA	Han，Pengcheng,et al."Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2".Cell 185.4(2022):630-640.e10.

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