中文版 | English
Title

Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Author
Corresponding AuthorHu, Genwen; Guo, Bing
Publication Years
2022-06-16
DOI
Source Title
EISSN
1477-3155
Volume20Issue:1
Abstract
Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high incidence and degree of malignancy as well as poor prognosis. Due to the existence of formidable blood-brain barrier (BBB) and the aggressive growth and infiltrating nature of GBM, timely diagnosis and treatment of GBM is still very challenging. Among different imaging modalities, magnetic resonance imaging (MRI) with merits including high soft tissue resolution, non-invasiveness and non-limited penetration depth has become the preferred tool for GBM diagnosis. Furthermore, multimodal imaging with combination of MRI and other imaging modalities would not only synergistically integrate the pros, but also overcome the certain limitation in each imaging modality, offering more accurate morphological and pathophysiological information of brain tumors. Since contrast agents contribute to amplify imaging signal output for unambiguous pin-pointing of tumors, tremendous efforts have been devoted to advances of contrast agents for MRI and multimodal imaging. Herein, we put special focus on summary of the most recent advances of not only MRI contrast agents including iron oxide-, manganese (Mn)-, gadolinium (Gd)-, F-19- and copper (Cu)-incorporated nanoplatforms for GBM imaging, but also dual-modal or triple-modal nanoprobes. Furthermore, potential obstacles and perspectives for future research and clinical translation of these contrast agents are discussed. We hope this review provides insights for scientists and students with interest in this area.
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Corresponding
Funding Project
Science and Technology Innovation Commission of Shenzhen["RCBS20200714114910141","JCYJ20210324132816039"] ; Harbin Institute of Technology (Shenzhen)["HA45001108","HA11409049"] ; Guangdong Natural Science Foundation[2022A1515011781] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110086]
WOS Research Area
Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS Subject
Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS Accession No
WOS:000812306300002
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:5
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343026
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Radiol, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China
5.Harbin Inst Technol, Shenzhen Key Lab Flexible Printed Elect Technol, Shenzhen 518055, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Zhuang, Danping,Zhang, Huifen,Hu, Genwen,et al. Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma[J]. JOURNAL OF NANOBIOTECHNOLOGY,2022,20(1).
APA
Zhuang, Danping,Zhang, Huifen,Hu, Genwen,&Guo, Bing.(2022).Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma.JOURNAL OF NANOBIOTECHNOLOGY,20(1).
MLA
Zhuang, Danping,et al."Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma".JOURNAL OF NANOBIOTECHNOLOGY 20.1(2022).
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