中文版 | English
Title

Transposable Elements in Pluripotent Stem Cells and Human Disease

Author
Corresponding AuthorHutchins, Andrew P.
Publication Years
2022-06-02
DOI
Source Title
EISSN
1664-8021
Volume13
Abstract
Transposable elements (TEs) are mobile genetic elements that can randomly integrate into other genomic sites. They have successfully replicated and now occupy around 40% of the total DNA sequence in humans. TEs in the genome have a complex relationship with the host cell, being both potentially deleterious and advantageous at the same time. Only a tiny minority of TEs are still capable of transposition, yet their fossilized sequence fragments are thought to be involved in various molecular processes, such as gene transcriptional activity, RNA stability and subcellular localization, and chromosomal architecture. TEs have also been implicated in biological processes, although it is often hard to reveal cause from correlation due to formidable technical issues in analyzing TEs. In this review, we compare and contrast two views of TE activity: one in the pluripotent state, where TEs are broadly beneficial, or at least mechanistically useful, and a second state in human disease, where TEs are uniformly considered harmful.
Keywords
URL[Source Record]
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Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Natural Science Foundation of China[31970589] ; Shenzhen Innovation Committee of Science and Technology["JCYJ20200109141018712","ZDSYS20200811144002008"]
WOS Research Area
Genetics & Heredity
WOS Subject
Genetics & Heredity
WOS Accession No
WOS:000812059300001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343035
DepartmentDepartment of Biology
生命科学学院
Affiliation
Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen Key Lab Gene Regulat & Syst Biol, Shenzhen, Peoples R China
First Author AffilicationDepartment of Biology;  School of Life Sciences
Corresponding Author AffilicationDepartment of Biology;  School of Life Sciences
First Author's First AffilicationDepartment of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Ma, Gang,Babarinde, Isaac A.,Zhou, Xuemeng,et al. Transposable Elements in Pluripotent Stem Cells and Human Disease[J]. FRONTIERS IN GENETICS,2022,13.
APA
Ma, Gang,Babarinde, Isaac A.,Zhou, Xuemeng,&Hutchins, Andrew P..(2022).Transposable Elements in Pluripotent Stem Cells and Human Disease.FRONTIERS IN GENETICS,13.
MLA
Ma, Gang,et al."Transposable Elements in Pluripotent Stem Cells and Human Disease".FRONTIERS IN GENETICS 13(2022).
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