中文版 | English
Title

Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design

Author
Corresponding AuthorShi, Lei
Publication Years
2022-05-01
DOI
Source Title
ISSN
2052-4129
Volume9Pages:3591-3597
Abstract
With the flourishing progress of modern medicinal chemistry, bicyclo[1.1.1]pentylamines (BCPAs) have come to the fore as bioisosteres of arylamine motifs to reduce the growing concern about the risks of arylamines related to metabolism, bioavailability, and excretion. In light of the prevalence and significance of BCPAs, an increasing number of new practical protocols to efficiently furnish these appealing molecules have been thus disclosed, which serve to shorten the long synthetic sequences or enable gram-scale syntheses through one-pot multicomponent processes, creating a novel chemical space and systematically streamlining drug design routes.
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China[21871067] ; Natural Science Foundation of Guangdong Province["2018A030313038","2021A1515010190"] ; Shenzhen Fundamental Research Projects[JCYJ20180306171838187] ; Open Project Program of State Key Laboratory of Elemento-Organic Chemistry[202009] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Fundamental Research Funds for the Central Universities[HIT.OCEF. 2021035]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Organic
WOS Accession No
WOS:000811771100001
Publisher
EI Accession Number
20222612272207
EI Keywords
Synthesis (chemical)
ESI Classification Code
Biochemistry:801.2 ; Chemical Reactions:802.2
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:7
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343039
Affiliation
1.Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
Corresponding Author AffilicationSouthern University of Science and Technology
Recommended Citation
GB/T 7714
Yu, Zhiyou,Shi, Lei. Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design[J]. Organic Chemistry Frontiers,2022,9:3591-3597.
APA
Yu, Zhiyou,&Shi, Lei.(2022).Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design.Organic Chemistry Frontiers,9,3591-3597.
MLA
Yu, Zhiyou,et al."Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design".Organic Chemistry Frontiers 9(2022):3591-3597.
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