| Title | Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design |
| Author | |
| Corresponding Author | Shi, Lei |
| Publication Years | 2022-05-01
|
| DOI | |
| Source Title | |
| ISSN | 2052-4129
|
| Volume | 9Pages:3591-3597 |
| Abstract | With the flourishing progress of modern medicinal chemistry, bicyclo[1.1.1]pentylamines (BCPAs) have come to the fore as bioisosteres of arylamine motifs to reduce the growing concern about the risks of arylamines related to metabolism, bioavailability, and excretion. In light of the prevalence and significance of BCPAs, an increasing number of new practical protocols to efficiently furnish these appealing molecules have been thus disclosed, which serve to shorten the long synthetic sequences or enable gram-scale syntheses through one-pot multicomponent processes, creating a novel chemical space and systematically streamlining drug design routes. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[21871067]
; Natural Science Foundation of Guangdong Province["2018A030313038","2021A1515010190"]
; Shenzhen Fundamental Research Projects[JCYJ20180306171838187]
; Open Project Program of State Key Laboratory of Elemento-Organic Chemistry[202009]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
; Fundamental Research Funds for the Central Universities[HIT.OCEF. 2021035]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000811771100001
|
| Publisher | |
| EI Accession Number | 20222612272207
|
| EI Keywords | Synthesis (chemical)
|
| ESI Classification Code | Biochemistry:801.2
; Chemical Reactions:802.2
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:6
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/343039 |
| Department | Southern University of Science and Technology |
| Affiliation | 1.Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China |
| Corresponding Author Affilication | Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
Yu, Zhiyou,Shi, Lei. Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design[J]. Organic Chemistry Frontiers,2022,9:3591-3597.
|
| APA |
Yu, Zhiyou,&Shi, Lei.(2022).Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design.Organic Chemistry Frontiers,9,3591-3597.
|
| MLA |
Yu, Zhiyou,et al."Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design".Organic Chemistry Frontiers 9(2022):3591-3597.
|
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