| Title | CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells |
| Author | |
| Corresponding Author | Kissler, Stephan |
| Publication Years | 2022-06-02
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| DOI | |
| Source Title | |
| ISSN | 1664-3224
|
| Volume | 13 |
| Abstract | CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| WOS Research Area | Immunology
|
| WOS Subject | Immunology
|
| WOS Accession No | WOS:000812094200001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/343055 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA 2.NIH, Sect Hematopoiesis & Lymphocyte Biol, Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Bethesda, MD USA 3.Rudolf Virchow Ctr Expt Biomed, Wurzburg, Germany 4.Cent South Univ, Xiangya Hosp 2, Dept Metab & Endocrinol, Changsha, Hunan, Peoples R China 5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med C, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 |
Schuster, Cornelia,Kiaf, Badr,Hatzihristidis, Teri,et al. CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells[J]. Frontiers in Immunology,2022,13.
|
| APA |
Schuster, Cornelia.,Kiaf, Badr.,Hatzihristidis, Teri.,Ruckdeschel, Anna.,Nieves-Bonilla, Janice.,...&Kissler, Stephan.(2022).CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells.Frontiers in Immunology,13.
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| MLA |
Schuster, Cornelia,et al."CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells".Frontiers in Immunology 13(2022).
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