中文版 | English
Title

CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells

Author
Corresponding AuthorKissler, Stephan
Publication Years
2022-06-02
DOI
Source Title
ISSN
1664-3224
Volume13
Abstract
CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile.
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Language
English
SUSTech Authorship
Others
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000812094200001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343055
DepartmentShenzhen People's Hospital
Affiliation
1.Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA
2.NIH, Sect Hematopoiesis & Lymphocyte Biol, Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Bethesda, MD USA
3.Rudolf Virchow Ctr Expt Biomed, Wurzburg, Germany
4.Cent South Univ, Xiangya Hosp 2, Dept Metab & Endocrinol, Changsha, Hunan, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med C, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Schuster, Cornelia,Kiaf, Badr,Hatzihristidis, Teri,et al. CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells[J]. Frontiers in Immunology,2022,13.
APA
Schuster, Cornelia.,Kiaf, Badr.,Hatzihristidis, Teri.,Ruckdeschel, Anna.,Nieves-Bonilla, Janice.,...&Kissler, Stephan.(2022).CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells.Frontiers in Immunology,13.
MLA
Schuster, Cornelia,et al."CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells".Frontiers in Immunology 13(2022).
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