| Title | Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation |
| Author | |
| Corresponding Author | Zhang, Yusen |
| Publication Years | 2022-06-01
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| DOI | |
| Source Title | |
| ISSN | 0393-6155
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| EISSN | 1724-6008
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| Abstract | Objective This study aimed to investigate the role of the alpha fetoprotein (AFP) ratio before and after radiofrequency ablation (RFA) in the prognosis of patients with liver cancer. Methods A total of 368 patients who underwent RFA for liver cancer in Shenzhen People's Hospital from 2010 to 2020 were randomly divided into the training group and the validation group. Levels of AFP before and after RFA were recorded and their ratios were calculated. Results Using the X-tile software, it was found that the optimal cut-off value of the AFP ratio in the training group was 37.9. Both in the training group and the validation group, the relapse-free survival and overall survival of patients with an AFP ratio <37.9 (high-risk group) were significantly shorter than those with an AFP ratio >37.9 (low-risk group) (training group, relapse-free survival, P = 0.0003; overall survival, P = 0.0186; validation group, relapse-free survival, P = 0.0490, overall survival, P = 0.0031). An AFP ratio Conclusion The AFP ratio can predict the prognosis of patients with liver cancer after RFA. An AFP ratio <37.9 is an independent risk factor for tumor recurrence and survival after RFA. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China["A2021230","SZXK015",52077216]
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| WOS Research Area | Biotechnology & Applied Microbiology
; Oncology
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| WOS Subject | Biotechnology & Applied Microbiology
; Oncology
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| WOS Accession No | WOS:000811526500001
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| Publisher | |
| ESI Research Field | CLINICAL MEDICINE
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| Data Source | Web of Science
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| Citation statistics |
Cited Times [WOS]:1
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/343059 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Jinan Univ, Clin Med Coll 2, Dept Hepatobiliary & Pancreas Surg, ShenZhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China 3.ShenZhen Peoples Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Luo, Biwei,Liu, Linsen,Bi, Jian'gang,et al. Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2022.
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| APA |
Luo, Biwei,Liu, Linsen,Bi, Jian'gang,Bao, Shiyun,&Zhang, Yusen.(2022).Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS.
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| MLA |
Luo, Biwei,et al."Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2022).
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