中文版 | English
Title

Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation

Author
Corresponding AuthorZhang, Yusen
Publication Years
2022-06-01
DOI
Source Title
ISSN
0393-6155
EISSN
1724-6008
Abstract
Objective This study aimed to investigate the role of the alpha fetoprotein (AFP) ratio before and after radiofrequency ablation (RFA) in the prognosis of patients with liver cancer. Methods A total of 368 patients who underwent RFA for liver cancer in Shenzhen People's Hospital from 2010 to 2020 were randomly divided into the training group and the validation group. Levels of AFP before and after RFA were recorded and their ratios were calculated. Results Using the X-tile software, it was found that the optimal cut-off value of the AFP ratio in the training group was 37.9. Both in the training group and the validation group, the relapse-free survival and overall survival of patients with an AFP ratio <37.9 (high-risk group) were significantly shorter than those with an AFP ratio >37.9 (low-risk group) (training group, relapse-free survival, P = 0.0003; overall survival, P = 0.0186; validation group, relapse-free survival, P = 0.0490, overall survival, P = 0.0031). An AFP ratio Conclusion The AFP ratio can predict the prognosis of patients with liver cancer after RFA. An AFP ratio <37.9 is an independent risk factor for tumor recurrence and survival after RFA.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China["A2021230","SZXK015",52077216]
WOS Research Area
Biotechnology & Applied Microbiology ; Oncology
WOS Subject
Biotechnology & Applied Microbiology ; Oncology
WOS Accession No
WOS:000811526500001
Publisher
ESI Research Field
CLINICAL MEDICINE
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343059
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Clin Med Coll 2, Dept Hepatobiliary & Pancreas Surg, ShenZhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.ShenZhen Peoples Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Luo, Biwei,Liu, Linsen,Bi, Jian'gang,et al. Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2022.
APA
Luo, Biwei,Liu, Linsen,Bi, Jian'gang,Bao, Shiyun,&Zhang, Yusen.(2022).Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS.
MLA
Luo, Biwei,et al."Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2022).
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