中文版 | English
Title

Spleen in viral Hepatitis-B liver fibrosis patients may have a reduced level of per unit micro-circulation: non-invasive diffusion MRI evidence with a surrogate marker

Author
Corresponding AuthorWang, Wei; Wang, Yi Xiang J.
Publication Years
2022-06-01
DOI
Source Title
ISSN
2472-6303
EISSN
2472-6311
Volume27Issue:3
Abstract
Y Spleen micro-perfusion level can be evaluated by DDVD (diffusion derived vessel density): DDVD (unit: au/pixel) = Sb0/ROIarea0 - Sb2/ROIarea2, where Sb0 and Sb2 refer to the spleen signal when b is 0 or 2 (s/mm(2)) and ROI is 'region-of-interest'. This study investigated whether spleen DDVD is altered in patients with viral hepatitis-b (VHB) liver fibrosis. Three datasets were retrospectively analysed. Shenzhen data-1 had 25 healthy volunteers and 15 VHB liver fibrosis patients. Changsha data had 24 healthy volunteers and 31 patients with VHB liver fibrosis. Shenzhen data-2 had 67 healthy volunteers. Shenzhen data-2 were measured by reader-1. Shenzhen data-1 were measured by reader-1 and reader-2. For Changsha data, reader-1 measured all subjects, while Reader-2 measured a random selection of 10 healthy volunteers and two patients from each liver fibrosis grade (total=8). Shenzhen data-2 showed in healthy volunteers there was no age-dependent change of spleen DDVD during 20 similar to 71 years old, and women had higher spleen DDVD values than those of men's (16.17 +/- 7.34 vs. 12.88 +/- 5.91, p=0.04). Changsha data by reader-1 showed patients with liver fibrosis had lower spleen DDVD values than those of healthy volunteers (median=16.24 vs. 23.54, p=0.0031). Results of reader-2 showed the same trend (median=11.64 vs. 23.33, p=0.0165). Shenzhen data-1 measured by reader-1 showed medians of spleen DDVD for patients and volunteers were 8.535 and 12.33 respectively; and those measured by reader-2 were 13.89 and 14.31 respectively. We conclude that diffusion MRI shows spleen DDVD, i.e., micro-circulation per volume tissue, is decreased in VHB liver fibrosis patients.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Hong Kong GRF Project[14109218]
WOS Research Area
Biochemistry & Molecular Biology ; Chemistry
WOS Subject
Biochemical Research Methods ; Chemistry, Analytical
WOS Accession No
WOS:000810509900004
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343066
DepartmentThe Third People's Hospital of Shenzhen
Affiliation
1.Chinese Univ Hong Kong, Fac Med, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Peoples Hosp Shenzhen 3,Dept Radiol, Shenzhen, Guangdong, Peoples R China
3.Cent South Univ, Xiangya Hosp 3, Dept Radiol, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Cun-Jing,Huang, Hua,Xiao, Ben-Heng,et al. Spleen in viral Hepatitis-B liver fibrosis patients may have a reduced level of per unit micro-circulation: non-invasive diffusion MRI evidence with a surrogate marker[J]. SLAS Technology,2022,27(3).
APA
Zheng, Cun-Jing,Huang, Hua,Xiao, Ben-Heng,Li, Ting,Wang, Wei,&Wang, Yi Xiang J..(2022).Spleen in viral Hepatitis-B liver fibrosis patients may have a reduced level of per unit micro-circulation: non-invasive diffusion MRI evidence with a surrogate marker.SLAS Technology,27(3).
MLA
Zheng, Cun-Jing,et al."Spleen in viral Hepatitis-B liver fibrosis patients may have a reduced level of per unit micro-circulation: non-invasive diffusion MRI evidence with a surrogate marker".SLAS Technology 27.3(2022).
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