中文版 | English
Title

meGPS: a multi-omics signature for hepatocellular carcinoma detection integrating methylome and transcriptome data

Author
Corresponding AuthorTsui, Stephen Kwok-Wing; Cheng, Lixin
Publication Years
2022-06-01
DOI
Source Title
ISSN
1367-4803
EISSN
1460-2059
Abstract
["Motivation: Hepatocellular carcinoma (HCC) is a primary malignancy with a poor prognosis. Recently, multi-omics molecular-level measurement enables HCC diagnosis and prognosis prediction, which is crucial for early intervention of personalized therapy to diminish mortality. Here, we introduce a novel strategy utilizing DNA methylation and RNA expression data to achieve a multi-omics gene pair signature (GPS) for HCC discrimination.","Results: The immune genes with negative correlations between expression and promoter methylation are enriched in the highly connected cancer-related pathway network, which are considered as the candidates for HCC detection. After that, we separately construct a methylation GPS (mGPS) and an expression GPS (eGPS), and then assemble them as a meGPS with five gene pairs, in which the significant methylation and expression changes occur between HCC tumor and non-tumor groups. Reliable performance has been validated by independent tissue (age, gender and etiology) and blood datasets. This study proposes a procedure for multi-omics GPS identification and develops a novel HCC signature using both methylome and transcriptome data, suggesting potential molecular targets for the detection and therapy of HCC."]
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Guangdong Basic and Applied Basic Research Foundation[2019A1515110097] ; General Research Fund of the Hong Kong Research Grants Council[14175617,14119420,14119219] ; Health and Medical Research Fund of the Food and Health Bureau of the Hong Kong Special Administrative Region government["06171016","07181266"]
WOS Research Area
Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS Subject
Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS Accession No
WOS:000809396400001
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:7
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/343088
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Clin Med Coll 2, Southern Univ Sci & Technol, Affiliated Hosp 1,Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China
2.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Dept Comp Sci & Engn, Hong Kong, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
First Author's First AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Wu, Qiong,Zheng, Xubin,Leung, Kwong-Sak,et al. meGPS: a multi-omics signature for hepatocellular carcinoma detection integrating methylome and transcriptome data[J]. BIOINFORMATICS,2022.
APA
Wu, Qiong,Zheng, Xubin,Leung, Kwong-Sak,Wong, Man-Hon,Tsui, Stephen Kwok-Wing,&Cheng, Lixin.(2022).meGPS: a multi-omics signature for hepatocellular carcinoma detection integrating methylome and transcriptome data.BIOINFORMATICS.
MLA
Wu, Qiong,et al."meGPS: a multi-omics signature for hepatocellular carcinoma detection integrating methylome and transcriptome data".BIOINFORMATICS (2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Wu, Qiong]'s Articles
[Zheng, Xubin]'s Articles
[Leung, Kwong-Sak]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Wu, Qiong]'s Articles
[Zheng, Xubin]'s Articles
[Leung, Kwong-Sak]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, Qiong]'s Articles
[Zheng, Xubin]'s Articles
[Leung, Kwong-Sak]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.