Experimental research on surface acoustic wave microfluidic atomization for drug delivery

Huang, Qing-Yun1,2; Le, Ying3; Hu, Hong1; Wan, Zhi-jian2; Ning, Jia1; Han, Jun-Long1

2022-05-13

10.1038/s41598-022-11132-9

Scientific Reports   Impact Factor & Quartile

2045-2322

This paper demonstrates that surface acoustic wave (SAW) atomization can produce suitable aerosol concentration and size distribution for efficient inhaled lung drug delivery and is a potential atomization device for asthma treatment. Using the SAW device, we present comprehensive experimental results exploring the complexity of the acoustic atomization process and the influence of input power, device frequency, and liquid flow rate on aerosol size distribution. It is hoped that these studies will explain the mechanism of SAW atomization aerosol generation and how they can be controlled. The insights from the high-speed flow visualization studies reveal that it is possible by setting the input power above 4.17 W, thus allowing atomization to occur from a relatively thin film, forming dense, monodisperse aerosols. Moreover, we found that the aerosol droplet size can be effectively changed by adjusting the input power and liquid flow rate to change the film conditions. In this work, we proposed a method to realize drug atomization by a microfluidic channel. A SU-8 flow channel was prepared on the surface of a piezoelectric substrate by photolithography technology. Combined with the silicon dioxide coating process and PDMS process closed microfluidic channel was prepared, and continuous drug atomization was provided to improve the deposition efficiency of drug atomization by microfluidic.

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National Natural Science Foundation of China (NSFC)[52175532] ; Shenzhen Science and Technology Research and Development Fund["JSGG20201201100410029","JSGG20201201100401004"]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000803217300002

NATURE PORTFOLIO

Web of Science

1.Harbin Inst Technol Shenzhen, Sch Mech Engn & Automat, Shenzhen 518055, Guangdong, Peoples R China
2.Shenzhen Polytech, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Endocr, Shenzhen 518020, Guangdong, Peoples R China

Huang, Qing-Yun,Le, Ying,Hu, Hong,et al. Experimental research on surface acoustic wave microfluidic atomization for drug delivery[J]. Scientific Reports,2022,12(1).

Huang, Qing-Yun,Le, Ying,Hu, Hong,Wan, Zhi-jian,Ning, Jia,&Han, Jun-Long.(2022).Experimental research on surface acoustic wave microfluidic atomization for drug delivery.Scientific Reports,12(1).

Huang, Qing-Yun,et al."Experimental research on surface acoustic wave microfluidic atomization for drug delivery".Scientific Reports 12.1(2022).