具有活性氧清除能力的水凝胶敷料治疗糖尿病溃疡创面的研究

慢性难愈合创面具有伤口情况复杂、易遭受细菌感染、治疗周期长和容易复发等特点，给患者带来严重的生理心理痛苦甚至是生命威胁，一直是临床医学界难以解决的重大问题，耗费社会大量的经济与医疗资源。其中，糖尿病溃疡创面占慢性难愈合创面的比例逐年增大，患者数量逐年上升，成为全世界亟待解决的公共医疗问题。糖尿病足溃疡的创面微环境非常的复杂，通常表现出严重的氧化应激现象，产生的过量活性氧(ROS) 不仅会引起强烈的炎症反应，还会抑制内源性干细胞和巨噬细胞的功能，阻碍伤口组织再生与血管的重建，导致伤口不愈合。所以，本研究着眼于糖尿病足溃疡创面的氧化应激现象，提出了消除创面过量活性氧重建修复微环境的治疗思路。基于氧化铈的 ROS清除能力，以及生物活性玻璃的软组织修复促进功能，本研究设计并制备了一种铈掺杂的生物活性玻璃，并将其负载于甲基纤维素温敏性水凝胶中制造创面敷料，进行治疗糖尿病溃疡创面的研究。体外研究结果表明，该水凝胶创面敷料具有体温响应固化特性以及良好的生物相容性，利用铈掺杂生物活性玻璃，对于细胞外和细胞内的 ROS均表现出优秀的清除效果。动物试验结果表明，该水凝胶创面敷料通过降低细胞受到的氧化应激程度，明显改善了糖尿病小鼠全层皮肤损伤的修复效果。因此，本研究开发的具有 ROS活性氧清除能力的水凝胶敷料，在治疗糖尿病溃疡创面方面具有很好的应用前景。

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