Title | In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control |
Author | |
Corresponding Author | Zhang, Chong; Wu, Decheng |
Publication Years | 2022-06-01
|
DOI | |
Source Title | |
ISSN | 2047-4830
|
EISSN | 2047-4849
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Volume | 10Pages:4218-4227 |
Abstract | Rapidly in situ forming adhesive hydrogels are promising candidates for efficient hemostasis due to their easy administration and minimal invasion. However, development of biocompatible and high-performance hemostatic hydrogels without any additional toxic agents remains a challenge. Herein, a series of novel injectable adhesive hydrogels based on N-hydroxysuccinimide (NHS) modified gamma-poly(glutamic acid) (gamma PGA-NHS) and tetra-armed poly(ethylene glycol) amine (Tetra-PEG-NH2) were developed. Among all samples, PGA(10)-PEG(15) and PGA(10)-PEG(20) hydrogels with higher PEG contents exhibited rapid gelation time (<20 s), strong mechanical strength (compression modulus up to similar to 75 kPa), good adhesive properties (similar to 15 kPa), and satisfactory burst pressure (similar to 18-20 kPa). As a result, PGA(10)-PEG(15) and PGA(10)-PEG(20) hydrogels showed a remarkable reduction in hemostasis time and blood loss compared with gauze and fibrin glue. More importantly, the PGA(10)-PEG(20) hydrogel was also successfully used to seal femoral arterial trauma. Subcutaneous implantation experiments indicated a good biocompatibility of the hydrogels in vivo. All these results strongly support that the developed PGA-PEG hydrogels could serve as promising hemostatic agents in emergency and clinical situations. |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | First
; Corresponding
|
Funding Project | Ministry of Science and Technology of China[2020YFA0908900]
; National Natural Science Foundation of China[21935011,21725403]
; Shenzhen Science and Technology Innovation Commission[KQTD20200820113012029]
|
WOS Research Area | Materials Science
|
WOS Subject | Materials Science, Biomaterials
|
WOS Accession No | WOS:000815215600001
|
Publisher | |
EI Accession Number | 20222712305945
|
EI Keywords | Adhesives
; Amino acids
; Biocompatibility
; Gelation
; Hydrogels
|
ESI Classification Code | Immunology:461.9.1
; Colloid Chemistry:801.3
; Chemical Operations:802.3
; Chemical Products Generally:804
; Organic Compounds:804.1
; Organic Polymers:815.1.1
|
Data Source | Web of Science
|
Citation statistics |
Cited Times [WOS]:4
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/347930 |
Department | Department of Biomedical Engineering |
Affiliation | Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China |
First Author Affilication | Department of Biomedical Engineering |
Corresponding Author Affilication | Department of Biomedical Engineering |
First Author's First Affilication | Department of Biomedical Engineering |
Recommended Citation GB/T 7714 |
Ye, Huijun,Xian, Yiwen,Li, Shurong,et al. In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control[J]. Biomaterials Science,2022,10:4218-4227.
|
APA |
Ye, Huijun,Xian, Yiwen,Li, Shurong,Zhang, Chong,&Wu, Decheng.(2022).In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control.Biomaterials Science,10,4218-4227.
|
MLA |
Ye, Huijun,et al."In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control".Biomaterials Science 10(2022):4218-4227.
|
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