中文版 | English
Title

In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control

Author
Corresponding AuthorZhang, Chong; Wu, Decheng
Publication Years
2022-06-01
DOI
Source Title
ISSN
2047-4830
EISSN
2047-4849
Volume10Pages:4218-4227
Abstract
Rapidly in situ forming adhesive hydrogels are promising candidates for efficient hemostasis due to their easy administration and minimal invasion. However, development of biocompatible and high-performance hemostatic hydrogels without any additional toxic agents remains a challenge. Herein, a series of novel injectable adhesive hydrogels based on N-hydroxysuccinimide (NHS) modified gamma-poly(glutamic acid) (gamma PGA-NHS) and tetra-armed poly(ethylene glycol) amine (Tetra-PEG-NH2) were developed. Among all samples, PGA(10)-PEG(15) and PGA(10)-PEG(20) hydrogels with higher PEG contents exhibited rapid gelation time (<20 s), strong mechanical strength (compression modulus up to similar to 75 kPa), good adhesive properties (similar to 15 kPa), and satisfactory burst pressure (similar to 18-20 kPa). As a result, PGA(10)-PEG(15) and PGA(10)-PEG(20) hydrogels showed a remarkable reduction in hemostasis time and blood loss compared with gauze and fibrin glue. More importantly, the PGA(10)-PEG(20) hydrogel was also successfully used to seal femoral arterial trauma. Subcutaneous implantation experiments indicated a good biocompatibility of the hydrogels in vivo. All these results strongly support that the developed PGA-PEG hydrogels could serve as promising hemostatic agents in emergency and clinical situations.
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China[21935011,21725403] ; Shenzhen Science and Technology Innovation Commission[KQTD20200820113012029]
WOS Research Area
Materials Science
WOS Subject
Materials Science, Biomaterials
WOS Accession No
WOS:000815215600001
Publisher
EI Accession Number
20222712305945
EI Keywords
Adhesives ; Amino acids ; Biocompatibility ; Gelation ; Hydrogels
ESI Classification Code
Immunology:461.9.1 ; Colloid Chemistry:801.3 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:4
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/347930
DepartmentDepartment of Biomedical Engineering
Affiliation
Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China
First Author AffilicationDepartment of Biomedical Engineering
Corresponding Author AffilicationDepartment of Biomedical Engineering
First Author's First AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Ye, Huijun,Xian, Yiwen,Li, Shurong,et al. In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control[J]. Biomaterials Science,2022,10:4218-4227.
APA
Ye, Huijun,Xian, Yiwen,Li, Shurong,Zhang, Chong,&Wu, Decheng.(2022).In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control.Biomaterials Science,10,4218-4227.
MLA
Ye, Huijun,et al."In situ forming injectable gamma-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control".Biomaterials Science 10(2022):4218-4227.
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