Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury

Huang, Deliang1; Peng, Jinghan1; Lei, Lin2; Chen, Yuanyuan1; Zhu, Zhibing1; Cai, Qingxian1; Deng, Yongcong2; Chen, Jun1

2022-05-01

10.14218/JCTH.2022.00077

Journal of Clinical and Translational Hepatology   Impact Factor & Quartile

2225-0719

2310-8819

Background and Aims: Anti-tuberculosis (anti-TB) druginduced liver injury (AT-DILI) is the most common side effect in patients who received anti-TB therapy. AT-DILI management includes monitoring liver function until symptoms arise in patients without high-risk factors for liver damage. The present study aimed to investigate the effect of liver function test (LFT) abnormal identification on the risk of DILI, including liver failure and anti-TB drug resistance in patients without high-risk factors. Methods: A total of 399 patients without high-risk factors for liver damage at baseline and who experienced LFT abnormal during the 6 months of first-line anti-TB treatment were enrolled. The Roussel Uclaf Causal Relationship Assessment Method (RUCAM, 2016) was applied in suspected DILI. The correlations between the time of LFT abnormal identification and DILI, liver failure, and anti-TB drug resistance were analyzed by smooth curve fitting and multivariable logistic regression models. Results: Among all study patients, 131 met the criteria for DILI with a mean RUCAM causality score of 8.86??0.63. 26/131 and 105/131 were in the probable grading and highly probable grading, respectively. The time of abnormal LFT identification was an independent predictor of DILI, liver failure, and anti-TB drug resistance in the crude model and after adjusting for other risk patient factors. The time of abnormal LFT identification was positively correlated with DILI, liver failure, and anti-TB drug resistance. The late identification group (>8 weeks) had the highest risk of DILI, followed by liver failure compared with the other two groups. Conclusions: The time to identification anti-TB drug resistance. The risk of DILI and liver failure

Liver function abnormal identification time Anti-tuberculosis in-duced liver injury Liver failure RUCAM causality scale

SCI

English

First ; Corresponding

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:000814304900001

XIA & HE PUBLISHING INC

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 2, Peoples Hosp Shenzhen 3, Dept Liver Dis, Shenzhen 518100, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Peoples Hosp Shenzhen 3, Dept TB, Shenzhen, Guangdong, Peoples R China

Huang, Deliang,Peng, Jinghan,Lei, Lin,et al. Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury[J]. Journal of Clinical and Translational Hepatology,2022,11(2).

Huang, Deliang.,Peng, Jinghan.,Lei, Lin.,Chen, Yuanyuan.,Zhu, Zhibing.,...&Chen, Jun.(2022).Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury.Journal of Clinical and Translational Hepatology,11(2).

Huang, Deliang,et al."Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury".Journal of Clinical and Translational Hepatology 11.2(2022).