Clinical and Gene Features of SARS-CoV-2-Positive Recurrence in Patients Recovered From COVID-19

Peng, Yuying1,2,3; Wang, Shaoqi4; Chai, Ruihuan5; Chen, Yong6; Li, Nan5; Zeng, Boning1,2; Tang, Qian1,2,3; Zheng, Kai5; Liang, Youfang5; Xie, Shouxia1,2; Huang, Wei7; Wang, Shaoxiang5; Wang, Xiao1,2,3

2022-06-08

10.3389/fmolb.2022.875418

FRONTIERS IN MOLECULAR BIOSCIENCES   Impact Factor & Quartile

2296-889X

There are still frequent reports that a number of recovered coronavirus disease 2019 (COVID-19) patients following discharge have re-detectable positive (RP) results by RT-PCR. Understanding the clinical and molecular characteristics of RP patients may have implications for curbing the COVID-19 pandemic. In this study, 318 COVID-19 convalescent patients, including 59 RP patients and 259 non-RP (NRP) patients, were enrolled. Among RP patients, women accounted for a significantly high proportion (67.8%), and the titers of IgG and IgM antibodies in this group were also significantly high. Differentially expressed genes (DEGs), including 692 upregulated and 383 downregulated genes, overlapped in two public GEO datasets containing RP and NRP blood cell samples. Enrichment analysis indicated that these DEGs were related to several key signaling pathways, such as viral infection, immune activation, and inflammatory responses. Importantly, 59 indicator genes constituting the core network exhibited high diagnostic values and were correlated with markers of different immune cells. Among these, 12 drug-related genes were associated with the RP results. Our work suggests that, in addition to clinically available features, blood cell transcriptome sequencing can be performed to obtain gene signatures for diagnosis of RP patients.

COVID-19 SARS-CoV-2 re-positive immune inflammation

SCI

English

Corresponding

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:000814727600001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Dept Pharm,Clin Med Coll 2, Shenzhen Key Lab Prevent & Treatment Severe Infec, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
3.Jinan Univ, Sch Pharm, Guangzhou, Peoples R China
4.Hubei Prov Corps Hosp Chinese Armed Police Force, Dept Internal Med, Wuhan, Peoples R China
5.Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Shenzhen, Peoples R China
6.Chinese PLA Ctr Dis Control & Prevent, Beijing, Peoples R China
7.Jinan Univ, Bacteriol & Antibacterial Resistance Surveillance, Shenzhen Inst Resp Dis,Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Southern Un, Shenzhen, Peoples R China

Peng, Yuying,Wang, Shaoqi,Chai, Ruihuan,et al. Clinical and Gene Features of SARS-CoV-2-Positive Recurrence in Patients Recovered From COVID-19[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9.

Peng, Yuying.,Wang, Shaoqi.,Chai, Ruihuan.,Chen, Yong.,Li, Nan.,...&Wang, Xiao.(2022).Clinical and Gene Features of SARS-CoV-2-Positive Recurrence in Patients Recovered From COVID-19.FRONTIERS IN MOLECULAR BIOSCIENCES,9.

Peng, Yuying,et al."Clinical and Gene Features of SARS-CoV-2-Positive Recurrence in Patients Recovered From COVID-19".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022).