| Title | The Roles of Adipose Tissue Macrophages in Human Disease |
| Author | |
| Corresponding Author | Zheng, Chunfu |
| Publication Years | 2022-06-09
|
| DOI | |
| Source Title | |
| ISSN | 1664-3224
|
| Volume | 13 |
| Abstract | Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | Natural Science Foundation of Shandong Province["ZR2020MH190","ZR2021MH086"]
; Medical Science and Technology Development Plans of Shandong province[202008021019]
; Project of Department of education of Guangdong province[2021KQNCX074]
|
| WOS Research Area | Immunology
|
| WOS Subject | Immunology
|
| WOS Accession No | WOS:000814856100001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:2
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/347976 |
| Department | The Third People's Hospital of Shenzhen |
| Affiliation | 1.Hebei North Univ, Cent Lab, Affiliated Hosp 1, Zhangjiakou, Peoples R China 2.Fujian Med Univ, Sch Basic Med Sci, Dept Immunol, Fuzhou, Peoples R China 3.Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Jinan, Peoples R China 4.Third Peoples Hosp Shenzhen, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China 5.Univ Penn, Sch Engn & Appl Sci, Philadelphia, PA USA 6.Shenzhen Univ, Shenzhen Key Lab, Gen Hosp, Shenzhen, Peoples R China 7.Shenzhen Univ, Dept Obstet & Gynecol, Gen Hosp, Shenzhen, Peoples R China 8.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada 9.Shandong Key Lab Oral Tissue Regenerat, Jinan, Peoples R China 10.Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, Jinan, Peoples R China 11.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Peoples R China |
| Recommended Citation GB/T 7714 |
Liang, Weizheng,Qi, Yanxu,Yi, Hongyang,et al. The Roles of Adipose Tissue Macrophages in Human Disease[J]. Frontiers in Immunology,2022,13.
|
| APA |
Liang, Weizheng.,Qi, Yanxu.,Yi, Hongyang.,Mao, Chenyu.,Meng, Qingxue.,...&Zheng, Chunfu.(2022).The Roles of Adipose Tissue Macrophages in Human Disease.Frontiers in Immunology,13.
|
| MLA |
Liang, Weizheng,et al."The Roles of Adipose Tissue Macrophages in Human Disease".Frontiers in Immunology 13(2022).
|
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