Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications
Microplastics (MPs; <5 mm) in the biosphere draws public concern about their potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation, and dermal contact. Ingestion and inhalation are the two major exposure pathways. An adult may consume approximately 5.1 × 10 items from table salts and up to 4.1 × 10 items via drinking water annually. Meanwhile, MP inhalation intake ranges from 0.9 × 10 to 7.9 × 10 items per year. The intake of MPs would be further distributed in different tissues and organs of humans depending on their sizes. The excretion has been discussed with the possible clearance ways (e.g., urine and feces). The review summarized the absorption, distribution, metabolic toxicity and excretion of MPs together with the attached chemicals. Moreover, the potential implications on humans are also discussed from in vitro and in vivo studies, and connecting the relationship between the physicochemical properties and the potential risks. This review will contribute to a better understanding of MPs as culprits and/or vectors linking to potential human health hazards, which will help outline the promising areas for further revealing the possible toxicity pathways.
Hong Kong Baptist University;National Natural Science Foundation of China;National Natural Science Foundation of China[RC-SGT2/18-19/SCI/008];
|WOS Research Area|
Engineering ; Environmental Sciences & Ecology
Engineering, Environmental ; Environmental Sciences
|WOS Accession No|
|EI Accession Number|
Health hazards ; Metabolism ; Microplastic ; Physicochemical properties ; Potable water ; Salts
|ESI Classification Code|
Water Resources:444 ; Water Pollution:453 ; Environmental Impact and Protection:454.2 ; Ecology and Ecosystems:454.3 ; Health Care:461.7 ; Physical Chemistry:801.4
|ESI Research Field|
Cited Times [WOS]:20
|Document Type||Journal Article|
|Department||School of Environmental Science and Engineering|
1.State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong
2.State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province,College of Environment,Zhejiang University of Technology,Hangzhou,Zhejiang,310014,China
4.State Key Laboratory of Environmental Criteria and Risk Assessment,Chinese Research Academy of Environmental Sciences,Beijing,100012,China
5.Consortium on Health,Environment,Education,and Research (CHEER),and Department of Science and Environmental Studies,The Education University of Hong Kong,Hong Kong
Wu，Pengfei,Lin，Siyi,Cao，Guodong,et al. Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,437.
Wu，Pengfei.,Lin，Siyi.,Cao，Guodong.,Wu，Jiabin.,Jin，Hangbiao.,...&Cai，Zongwei.(2022).Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications.JOURNAL OF HAZARDOUS MATERIALS,437.
Wu，Pengfei,et al."Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications".JOURNAL OF HAZARDOUS MATERIALS 437(2022).
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