| Title | The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China |
| Author | |
| Corresponding Author | Lu，Shuihua |
| Publication Years | 2022-09-01
|
| DOI | |
| Source Title | |
| ISSN | 1201-9712
|
| EISSN | 1878-3511
|
| Volume | 122Pages:321-326 |
| Abstract | Objectives: In this study, we aimed to verify whether Bacillus Calmette–Guérin (BCG) can protect first-year college students against Mycobacterium tuberculosis (MTB) infection by the recombinant fusion protein ESAT6-CFP10 skin test (ECST) or the tuberculin skin test (TST). Methods: We conducted a cross-sectional study to assess risk factors for latent tuberculosis infection (LTBI). Vaccine effectiveness of BCG against LTBI, measured by ECST and TST separately, was assessed using multivariable logistic regression. Results: A total of 7351 college freshmen accepted ECST, whereas 7228 accepted TST. A total of 263 (3.58%) tested positive with ECST and 581 (8.04%) tested positive with TST. BCG was significantly associated with LTBI (ECST: adjusted odds ratio (aOR) = 0.26; 95% CI 0.09 to 0.73; TST: aOR = 0.25; 95% CI 0.13 to 0.49). The BCG protective effect on freshmen living in rural areas (ECST: aOR = 0.16; 95% CI 0.04 to 0.55; TST: aOR = 0.12; 95% CI 0.04 to 0.33) is better than that of freshmen living in cities (ECST: aOR = 0.53; 95% CI 0.07 to 4.03; TST: aOR = 0.44; 95% CI 0.17 to 1.16). Conclusions: Protection against LTBI was strongly associated with BCG vaccination. A novel skin test (ECST) may underestimate the protective effects of BCG in college freshmen. BCG has better protection in areas with a slightly higher incidence of LTBI. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | Hunan Province Science and Tech-nology Major project[20200855]
|
| WOS Research Area | Infectious Diseases
|
| WOS Subject | Infectious Diseases
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| WOS Accession No | WOS:000836319700016
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| Publisher | |
| ESI Research Field | IMMUNOLOGY
|
| Scopus EID | 2-s2.0-85132726703
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/352475 |
| Department | School of Medicine 南方科技大学第二附属医院 |
| Affiliation | 1.Department of Pulmonary Medicine,Shanghai Public Health Clinical Center,Shanghai,China 2.Department of Infectious Disease and Public Health,Central Hospital of Xiangtan,Hunan province,China 3.Xiangtan Center for Disease Control and Prevention,Hunan province,China 4.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518112,China |
| Corresponding Author Affilication | School of Medicine; The Third People's Hospital of Shenzhen |
| Recommended Citation GB/T 7714 |
Huang，Wei,Fang，Zhixiong,Luo，Si,et al. The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2022,122:321-326.
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| APA |
Huang，Wei.,Fang，Zhixiong.,Luo，Si.,Lin，Sha.,Xu，Lei.,...&Lu，Shuihua.(2022).The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,122,321-326.
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| MLA |
Huang，Wei,et al."The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 122(2022):321-326.
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