Electrochemical Decarboxylative Coupling of N-Substituted Glycines under Air: Access to C3-Aminomethylated Imidazo[1,2-a]pyridines

Li，Sifeng1; Li，Xingchen1,2; Wang，Taimin1,2; Yang，Qingjing4; Ouyang，Zijun1; Chen，Jieyu1; Zhai，Hongbin3; Li，Xiao2; Cheng，Bin1,2

2022

10.1002/adsc.202200339

ADVANCED SYNTHESIS & CATALYSIS   Impact Factor & Quartile

1615-4150

1615-4169

An electrochemical decarboxylative aminomethylation reaction of imidazo[1,2-a]pyridines with various N-substituted glycines in acetonitrile at room temperature has been described. The reaction could be conducted under light-free, catalyst-free, oxidant-free, and air conditions, affording the C3-aminomethylated imidazo[1,2-a]pyridines in good to high yields. Remarkably, N-aryl, N,N-dialkyl, and N-alkyl-N-aryl glycines are all well-tolerated in this easily handled protocol, which further expands the chemical space of bioactive imidazo[1,2-a]pyridine derivatives. (Figure presented.).

aminomethylation decarboxylative coupling electrochemical glycine imidazo[1,2-a]pyridine

English

Others

2-s2.0-85133044689

Scopus

1.Institute of Marine Biomedicine/Postdoctoral Innovation Practice Base,Shenzhen Polytechnic,Shenzhen,518055,China
2.School of Chemical Engineering,University of Science and Technology Liaoning,Anshan,114051,China
3.State Key Laboratory of Chemical Oncogenomics,Shenzhen Engineering Laboratory of Nano Drug Slow-Release,Peking University Shenzhen Graduate School,Shenzhen,518055,China
4.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China

Li，Sifeng,Li，Xingchen,Wang，Taimin,et al. Electrochemical Decarboxylative Coupling of N-Substituted Glycines under Air: Access to C3-Aminomethylated Imidazo[1,2-a]pyridines[J]. ADVANCED SYNTHESIS & CATALYSIS,2022.

Li，Sifeng.,Li，Xingchen.,Wang，Taimin.,Yang，Qingjing.,Ouyang，Zijun.,...&Cheng，Bin.(2022).Electrochemical Decarboxylative Coupling of N-Substituted Glycines under Air: Access to C3-Aminomethylated Imidazo[1,2-a]pyridines.ADVANCED SYNTHESIS & CATALYSIS.

Li，Sifeng,et al."Electrochemical Decarboxylative Coupling of N-Substituted Glycines under Air: Access to C3-Aminomethylated Imidazo[1,2-a]pyridines".ADVANCED SYNTHESIS & CATALYSIS (2022).