| Title | Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study |
| Author | |
| Corresponding Author | Yang, Jun-bo; Sun, Dong-lin |
| Publication Years | 2022-06-15
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| DOI | |
| Source Title | |
| ISSN | 2296-861X
|
| Volume | 9 |
| Abstract | BackgroundWhile the relationship between blood pressure and blood lead has been studied more extensively, the effect of high-density lipoprotein (HDL) concentration on this relationship remains uncertain. Therefore, this study aimed to determine the effect of HDL concentration on the relationship between blood lead and blood pressure. MethodsThe research used cross-sectional data from the 2005 to 2014 National Health and Nutrition Examination Survey (NHANES), which included 16,451 participants aged 20-60 years. Multivariable linear regression was used to evaluate the correlation among blood lead, systolic blood pressure (SBP), and diastolic blood pressure (DBP). HDL concentration was determined by low HDL concentration (<= 49 mg/dl) and high HDL concentration (>49 mg/dl) stratified. The effect of HDL concentration was assessed by an interaction test between blood lead and SBP in multivariable linear regression. ResultsIn this cross-sectional research, we identified a positive correlation between blood lead and SBP, but not DBP. The relationship between blood lead and SBP was different in the group with low and high HDL concentrations (beta: 0.21 95% Cl:-0.05-0.46 vs. beta:0.47 95% Cl: 0.15-0.79). In addition, high HDL significantly altered the positive correlation between blood lead and SBP (P-value of interaction < 0.001). ConclusionThe study suggests an interaction between HDL and blood lead in elevating SBP, which may have important clinical implications. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
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| WOS Research Area | Nutrition & Dietetics
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| WOS Subject | Nutrition & Dietetics
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| WOS Accession No | WOS:000817975200001
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| Publisher | |
| Data Source | Web of Science
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| Citation statistics |
Cited Times [WOS]:0
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/353406 |
| Department | School of Medicine 南方科技大学第二附属医院 |
| Affiliation | 1.Guangzhou Med Univ, Clin Sch 2, Dept Clin Med, Guangzhou, Peoples R China 2.Guangzhou Med Univ, Clin Sch 2, Dept Anesthesiol, Guangzhou, Peoples R China 3.Guangzhou Med Univ, Clin Sch 2, Dept Med Imaging, Guangzhou, Peoples R China 4.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China 5.Southern Univ Sci & Technol, Affiliated Hosp Sch Med 2, Dept Gastrointestinal Surg, Shenzhen, Peoples R China 6.Shenzhen Third Peoples Hosp, Shenzhen, Peoples R China 7.Guangzhou Med Univ, Guangzhou, Peoples R China |
| Corresponding Author Affilication | School of Medicine |
| Recommended Citation GB/T 7714 |
Hu, Biao,He, Pei-yao,Zhong, Nan-nan,et al. Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study[J]. Frontiers in Nutrition,2022,9.
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| APA |
Hu, Biao.,He, Pei-yao.,Zhong, Nan-nan.,Gao, Zi-min.,Guo, Jiang-long.,...&Sun, Dong-lin.(2022).Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study.Frontiers in Nutrition,9.
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| MLA |
Hu, Biao,et al."Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study".Frontiers in Nutrition 9(2022).
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