A strain-programmed patch for the healing of diabetic wounds

Theocharidis, Georgios1,2; Yuk, Hyunwoo3,11; Roh, Heejung3; Wang, Liu3,12; Mezghani, Ikram1,2; Wu, Jingjing3,4; Kafanas, Antonios5; Contreras, Mauricio6; Sumpio, Brandon1,2; Li, Zhuqing1,2; Wang, Enya1,2; Chen, Lihong1,2; Guo, Chuan Fei4; Jayaswal, Navin1,2; Katopodi, Xanthi-Leda7; Kalavros, Nikolaos7; Nabzdyk, Christoph S.8; Vlachos, Ioannis S.7,9; Veves, Aristidis1,2; Zhao, Xuanhe3,10

2022-07-01

10.1038/s41551-022-00905-2

Nature Biomedical Engineering   Impact Factor & Quartile

2157-846X

["A polymer patch that rapidly and robustly adheres to diabetic wounds and contracts in a pre-programmed manner promotes wound closure and re-epithelialization, as shown in mouse and human skin, in mini-pigs and in humanized mice.","Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds."]

SCI ; EI

English

Others

Defense Advanced Research Projects Agency (DARPA)[GG0015670] ; Department of Defense Congressionally Directed Medical Research Programs (CDMRP)[PR200524P1]

Engineering

Engineering, Biomedical

WOS:000820557400003

NATURE PORTFOLIO

20222712326473

Adhesives ; Cell culture

Web of Science

1.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Joslin Beth Israel Deaconess Foot Ctr, Boston, MA 02115 USA
2.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Rongxiang Xu MD Ctr Regenerat Therapeut, Boston, MA 02115 USA
3.MIT, Dept Mech Engn, Cambridge, MA 02139 USA
4.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen, Peoples R China
5.Northern Lincolnshire & Goole NHS Fdn Trust, Lincoln Cty Hosp, Lincoln, Lincs, England
6.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Surg, Div Vasc Surg, Boston, MA 02115 USA
7.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Canc Res Inst,HMS Initiat RNA Med, Boston, MA 02115 USA
8.Mayo Clin, Dept Anesthesiol & Perioperat Med, Rochester, MN USA
9.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
10.MIT, Dept Civil & Environm Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA
11.SanaHeal Inc, Boston, MA 02115 USA
12.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei, Anhui, Peoples R China

Theocharidis, Georgios,Yuk, Hyunwoo,Roh, Heejung,et al. A strain-programmed patch for the healing of diabetic wounds[J]. Nature Biomedical Engineering,2022.

Theocharidis, Georgios.,Yuk, Hyunwoo.,Roh, Heejung.,Wang, Liu.,Mezghani, Ikram.,...&Zhao, Xuanhe.(2022).A strain-programmed patch for the healing of diabetic wounds.Nature Biomedical Engineering.

Theocharidis, Georgios,et al."A strain-programmed patch for the healing of diabetic wounds".Nature Biomedical Engineering (2022).