中文版 | English
Title

A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

Author
Corresponding AuthorMa,Guixing; Cao,Huiling
Publication Years
2023-02-01
DOI
Source Title
EISSN
2452-199X
Volume20Pages:610-626
Abstract
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation, angiogenesis, collagen formation. Furthermore, we find that ZnMet could inhibit reactive oxygen species (ROS) production through activation of autophagy, thereby protecting cell from oxidative stress induced damage and promoting healing of skin wound. ZnMet complex exerts better effects on promoting skin wound healing than ZnCl2 or metformin alone. ZnMet complex also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli, which could reduce the incidence of skin wound infections. Collectively, we demonstrate that sprayable PF127 could be used as a new drug delivery system for treatment of skin injury. The advantages of this sprayable system are obvious: (1) It is convenient to use; (2) The hydrogel can cover irregular skin defect sites evenly in a liquid state. In combination with this system, we establish a novel sprayable adhesive (ZnMet-PF127) and demonstrate that it is a potential clinical treatment for traumatic skin defect and burn skin injury.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Key Research and Development Program of China[2019YFA0906001] ; National Natural Science Foundation of China["82022047","81972100"] ; Guangdong Provincial Science and Technology Innovation Council[2017B030301018]
WOS Research Area
Engineering ; Materials Science
WOS Subject
Engineering, Biomedical ; Materials Science, Biomaterials
WOS Accession No
WOS:000830023100001
Publisher
Scopus EID
2-s2.0-85133424556
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttps://kc.sustech.edu.cn/handle/2SGJ60CL/355657
DepartmentDepartment of Biology
南方科技大学医学院
工学院_生物医学工程系
南方科技大学第一附属医院
南方科技大学医学院_生物化学系
Affiliation
1.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen,518055,China
2.Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518055,China
First Author AffilicationDepartment of Biology;  Department of Biochemistry;  School of Medicine
Corresponding Author AffilicationDepartment of Biology;  Department of Biochemistry;  School of Medicine
First Author's First AffilicationDepartment of Biology;  Department of Biochemistry;  School of Medicine
Recommended Citation
GB/T 7714
Liu,Zhengwei,Tang,Wanze,Liu,Jiayi,et al. A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound[J]. BIOACTIVE MATERIALS,2023,20:610-626.
APA
Liu,Zhengwei.,Tang,Wanze.,Liu,Jiayi.,Han,Yingying.,Yan,Qinnan.,...&Cao,Huiling.(2023).A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound.BIOACTIVE MATERIALS,20,610-626.
MLA
Liu,Zhengwei,et al."A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound".BIOACTIVE MATERIALS 20(2023):610-626.
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