中文版 | English
Title

Orthogonal Access to alpha-/beta-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations

Author
Corresponding AuthorShu, Wei
Publication Years
2022-07-01
DOI
Source Title
ISSN
1433-7851
EISSN
1521-3773
Abstract

Linear, alpha-branched, and beta-branched aliphatic amines are widespread in pharmaceuticals, agrochemicals, and fine chemicals. Thus, the development of direct and efficient methods to these structures in a tunable manner is highly desirable yet challenging. Herein, a catalyst-controlled synthesis of alpha-branched, beta-branched and linear aliphatic amines from Ni/Co-catalyzed regio- and site-selective hydroalkylations of alkenyl amines with alkyl halides is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to alpha-branched, beta-branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chemistry to catalytically repurpose three types of alkyl amines under mild conditions.

Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First ; Corresponding
Funding Project
NSFC[
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000823858300001
Publisher
EI Accession Number
20222912365282
EI Keywords
Agricultural chemicals ; Catalysts ; Cobalt compounds ; Hydrides ; Nickel compounds
ESI Classification Code
Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Agricultural Chemicals:821.2
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Publication Status
正式出版
Citation statistics
Cited Times [WOS]:18
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/355826
DepartmentDepartment of Chemistry
深圳格拉布斯研究院
Affiliation
1.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
3.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
First Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute;  Southern University of Science and Technology
Corresponding Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute;  Southern University of Science and Technology
First Author's First AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
Recommended Citation
GB/T 7714
Yang, Peng-Fei,Shu, Wei. Orthogonal Access to alpha-/beta-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
APA
Yang, Peng-Fei,&Shu, Wei.(2022).Orthogonal Access to alpha-/beta-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA
Yang, Peng-Fei,et al."Orthogonal Access to alpha-/beta-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).
Files in This Item:
File Name/Size DocType Version Access License
ACIE-2022, 61, e2022(10938KB) Restricted Access--
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