| Title | Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China |
| Author | |
| Corresponding Author | Xiao, Yonghong |
| Publication Years | 2022-06-22
|
| DOI | |
| Source Title | |
| ISSN | 2235-2988
|
| Volume | 12 |
| Abstract | Aztreonam/avibactam (AZA), as one of the novel beta-lactamases and beta-lactamase inhibitor combinations, is considered to be a promising option for bloodstream infection (BSI) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp). However, decreased susceptibility of AZA activity in Enterobacterales has been reported. The aim of this study was to identify the mechanisms of BSI CR-Kp with decreased susceptibility of AZA (minimal inhibitory concentration above 16/4 mg/L) (AZAH-Kp). Nine BSI AZAH-Kp isolates were screened from 317 CR-Kp isolates in Blood Bacterial Resistant Investigation Collaborative System (BRICS) program. Whole genome sequencing, bioinformatics analysis, and the relative expression of bla(KPC), ompK35, and ompK37 were explored for CR-Kp with decreased susceptibility to AZA. The results revealed that elevated inhibitory concentration of AZA has emerged in CR-Kp before previous clinical exposure. In addition, decreased AZA susceptibility was associated with higher KPC expression and changes in OmpK35-37. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| WOS Research Area | Immunology
; Microbiology
|
| WOS Subject | Immunology
; Microbiology
|
| WOS Accession No | WOS:000822591900001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/355837 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Zhejiang Univ, Sch Med, Hangzhou, Peoples R China 2.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Clin Med Coll 2, Shenzhen, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen, Peoples R China |
| Recommended Citation GB/T 7714 |
Yu, Wei,Shen, Ping,Chen, Yunbo,et al. Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China[J]. Frontiers in Cellular and Infection Microbiology,2022,12.
|
| APA |
Yu, Wei,Shen, Ping,Chen, Yunbo,Zhou, Kai,Chi, Xiaohui,&Xiao, Yonghong.(2022).Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China.Frontiers in Cellular and Infection Microbiology,12.
|
| MLA |
Yu, Wei,et al."Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China".Frontiers in Cellular and Infection Microbiology 12(2022).
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