中文版 | English
Title

Gamma-Glutamyl Transpeptidase-to-Platelet ratio predicts liver fibrosis in patients with concomitant chronic hepatitis B and nonalcoholic fatty liver disease

Author
Corresponding AuthorChen, Mingfa; Yang, Liuqing
Publication Years
2022-07-01
DOI
Source Title
ISSN
0887-8013
EISSN
1098-2825
Abstract
Objectives The aim of this study was to compare the correlation of gamma-glutamyl transpeptidase-to-platelet ratio (GPR), aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis index-4 (FIB-4), and liver stiffness measurement (LSM) in the diagnosis of liver fibrosis, and perform a diagnostic value of GPR for predicting fibrosis in CHB patients with NAFLD. Methods A retrospective study was conducted on CHB patients concurrent with NAFLD between September 2019 and December 2020. They were divided into control group (LSM <= 9.7 kpa) and fibrosis group (LSM >= 9.8 kpa). Demographic data were collected; ALT, AST, and PLT were also detected. LSM was measured by transient elastography (TE). The GPR, APRI, and FIB-4 were calculated. The correlation between GPR, APRI, FIB-4, and LSM was compared. The accuracy of predicting liver fibrosis using GPR, APRI, and FIB-4 was assessed. Results Eighty-five CHB patients with NAFLD were enrolled. Multivariate analysis showed that age (p = 0.005), GGT (p = 0.001), and PLT (p = 0.013) were the independent risk factors for LSM. The GPR (p = 0.008), APRI (p = 0.001), and FIB-4 (p = 0.001) values in fibrosis group were higher than control group. Pearson linear correlation was used to analyze the correlations between LSM and GPR, APRI, and FIB-4. LSM was correlated with GPR, APRI, and FIB-4. The AUCs of GPR, APRI, and FIB4 were 0.805, 0.766, and 0.826 in assessing liver fibrosis, respectively. No significant differences in the areas of GPR were comparable to that of APRI and FIB-4. Conclusion GPR has a good correlation with LSM in assessing liver fibrosis and can be used as a noninvasive index for the assessment of liver fibrosis in patients with concomitant CHB and NAFLD.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Shenzhen Luohu Soft Science Project["LX20191307","LX20201108"]
WOS Research Area
Medical Laboratory Technology
WOS Subject
Medical Laboratory Technology
WOS Accession No
WOS:000822305100001
Publisher
ESI Research Field
CLINICAL MEDICINE
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/355856
DepartmentThe Third People's Hospital of Shenzhen
Affiliation
1.Shenzhen Univ, ShenZhen LuoHu Peoples Hosp, Dept Hepatol, Affiliated Hosp 3, Shenzhen 518000, Guangdong, Peoples R China
2.Shenzhen Univ, Shenzhen Luohu Peoples Hosp, Dept Med Examinat, Affiliated Hosp 3, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Infect Dis, Affiliated Hosp 2, Shenzhen 518112, Guangdong, Peoples R China
Corresponding Author AffilicationThe Third People's Hospital of Shenzhen
Recommended Citation
GB/T 7714
Luo, Jie,Du, Zhan,Liang, Dongli,et al. Gamma-Glutamyl Transpeptidase-to-Platelet ratio predicts liver fibrosis in patients with concomitant chronic hepatitis B and nonalcoholic fatty liver disease[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2022.
APA
Luo, Jie.,Du, Zhan.,Liang, Dongli.,Li, Manni.,Yin, Yanyao.,...&Yang, Liuqing.(2022).Gamma-Glutamyl Transpeptidase-to-Platelet ratio predicts liver fibrosis in patients with concomitant chronic hepatitis B and nonalcoholic fatty liver disease.JOURNAL OF CLINICAL LABORATORY ANALYSIS.
MLA
Luo, Jie,et al."Gamma-Glutamyl Transpeptidase-to-Platelet ratio predicts liver fibrosis in patients with concomitant chronic hepatitis B and nonalcoholic fatty liver disease".JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022).
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