Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study

Li，Dapeng1; Liao，Xuejiao1,2; Ma，Zhenghua2; Zhang，Lina2; Dong，Jingke2; Zheng，Guoqin2; Zi，Mei3; Peng，Wujian4; Wei，Lanlan1; Li，Zhiyan5; Kong，Yingjun3; Wang，Lifei6; Liu，Dongjing1; Wang，Fang1; He，Qing1; Li，Guobao7; Zhang，Zheng1,8,9; Liu，Lei1,8

2022-07-10

10.1186/s13613-022-01034-4

Annals of Intensive Care   Impact Factor & Quartile

2110-5820

2110-5820

Background The long-term clinical status of coronavirus disease 2019 (COVID-19) in recovered patients remains largely unknown. This prospective cohort study evaluated clinical status of COVID-19 and explored the associated risk factors. Methods At the outpatient visit, patients underwent routine blood tests, physical examinations, pulmonary function tests, 6-min walk test, high-resolution computed tomography (CT) of the chest, and extrapulmonary organ function tests. Results 230 patients were analyzed. Half (52.7%) reported at least one symptom, most commonly fatigue (20.3%) and sleep difficulties (15.8%). Anxiety (8.2%), depression (11.3%), post-traumatic symptoms (10.3%), and sleep disorders (26.3%) were also reported. Diffusion impairments were found in 35.4% of the patients. Abnormal chest CT scans were present in 63.5% of the patients, mainly reticulation and ground-glass opacities. Further, a persistent decline in kidney function was observed after discharge. SARS-CoV-2-specific antibodies of IgA, IgG, and IgM were positive in 56.4%, 96.3%, and 15.2% of patients, respectively. Multivariable logistic regression showed that disease severity, age, and sex were closely related to patient recovery. Conclusions One year after hospital discharge, patients recovered from COVID-19 continued to experience both pulmonary and extrapulmonary dysfunction. While paying attention to pulmonary manifestations of COVID-19, follow-up studies on extrapulmonary manifestations should be strengthened.

COVID-19 Pulmonary dysfunction Extrapulmonary dysfunction SARS-CoV-2 antibodies Risk factor

SCI

English

First ; Corresponding

National Science Fund for Distinguished Young Scholars[82025022] ; Central Charity Fund of Chinese Academy of Medical Science[2020-PT310-009] ; Science and Technology Innovation Committee of Shenzhen Municipality["JSGG20200225152848007","JSGG20200207155251653","JSGG20220226090002003"] ; Emergency Key Program of Guangzhou Laboratory[EKPG21-29]

General & Internal Medicine

Critical Care Medicine

WOS:000824891000001

SPRINGER

2-s2.0-85133914371

Web of Science

1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital; The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
2.Department of Chronic Disease Follow-Up,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
3.Department of Respiratory Medicine,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
4.Department of Nephrology,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
5.Department of Ultrasound,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
6.Department of Radiology,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
7.Department of the Third Pulmonary Disease,Shenzhen Third People’s Hospital,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
8.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China
9.Guangdong Key Laboratory for Anti-Infection Drug Quality Evaluation,Shenzhen,No. 29, Bulan Road, Longgang district,518112,China

Li，Dapeng,Liao，Xuejiao,Ma，Zhenghua,et al. Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study[J]. Annals of Intensive Care,2022,12(1).

Li，Dapeng.,Liao，Xuejiao.,Ma，Zhenghua.,Zhang，Lina.,Dong，Jingke.,...&Liu，Lei.(2022).Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study.Annals of Intensive Care,12(1).

Li，Dapeng,et al."Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study".Annals of Intensive Care 12.1(2022).