Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults

Li，Fu Rong1,2; Wu，Ke Yi2; Fan，Wei Dong2; Chen，Guo Chong3,4; Tian，Haili5; Wu，Xian Bo2

2022-09-01

10.1016/j.ecoenv.2022.113835

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY   Impact Factor & Quartile

0147-6513

1090-2414

Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant. Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Crohn's disease, two subtypes of IBD, among middle and old aged adults in the UK. We also explored potential susceptible subgroups. Methods: We used data from the UK Biobank study. Information on air pollution, including PM2.5, PM2.5-10, PM10 as well as NO(2 )and NOx were estimated using the Land Use Regression model. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a median follow-up of 11.7 years, 1872 incident ulcerative colitis and 865 incident Crohn's disease cases were identified among 455,210 IBD-free participants. HRs (95% CIs) of ulcerative colitis associated with each 1 interquartile range (IQR) increase in PM2.5, PM2.5-10, PM10, NO2, and NOx were 1.06 (1.01, 1.12), 1.03 (0.99, 1.08), 1.09 (1.03, 1.16), 1.12 (1.07, 1.19), and 1.07 (1.02, 1.12), respectively. The associations between all the air pollutants and risk of Crohn's disease were null. Smoking status and sex appeared to respectively modify the associations between some air pollutants and risk of ulcerative colitis and Crohn's disease. Conclusion: Long-term exposure to various air pollutants was associated with the risk of incident ulcerative colitis but not Crohn's disease, highlighting the importance of developing environmental health strategy to reduce the burden of ulcerative colitis.

Inflammatory bowel disease Air pollution Epidemiology

SCI

English

First

National Natural Science Founda-tion of China[82173607] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515011684] ; Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease Research[2020B1212060042] ; Guangzhou Science and Technology Project[202102080597] ; Humanities and Social Sciences Youth Fund of Ministry of Education[21YJC890030]

Environmental Sciences & Ecology ; Toxicology

Environmental Sciences ; Toxicology

WOS:000829841500008

ACADEMIC PRESS INC ELSEVIER SCIENCE

ENVIRONMENT/ECOLOGY

2-s2.0-85133752303

Web of Science

1.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
2.Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou,China
3.Department of Nutrition and Food Hygiene,School of Public Health,Soochow University,Suzhou,China
4.Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,United States
5.School of Kinesiology,Shanghai University of Sport,Shanghai,China

Li，Fu Rong,Wu，Ke Yi,Fan，Wei Dong,et al. Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,242.

Li，Fu Rong,Wu，Ke Yi,Fan，Wei Dong,Chen，Guo Chong,Tian，Haili,&Wu，Xian Bo.(2022).Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,242.

Li，Fu Rong,et al."Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 242(2022).