中文版 | English
Title

Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time courses

Author
Corresponding AuthorLiu,Luping; Ju,Jun
Publication Years
2022-08-10
DOI
Source Title
ISSN
0304-3940
EISSN
1872-7972
Volume785
Abstract

Parvalbumin-expressing (PV) interneurons fast inhibit excitatory neurons in various brain areas. Perineuronal nets (PNNs), accumulating around PV neurons, have been shown to play critical roles in neuronal function and plasticity. The cellular mechanisms underlying their functions are still in debate, for example, do PNNs contribute significantly to the excitability of inhibitory neurons especially those containing PV? On the other hand, whether PNNs have significant contributions to synaptic transmission of PV neurons is much less unknown. In this study, we designed experiments to address these questions and found that removing PNNs in vivo using chondroitinase ABC (ChABC) led to distinct changes in neuronal excitability and synaptic transmission, depending on the duration of ChABC treatment. The results showed 7 days after ChABC treatment reduced both intrinsic excitability of PV neurons and synaptic transmission to both PV neurons and excitatory neurons in the primary visual cortex. However, 1 day after ChABC treatment digested PNNs effectively but had no effects on intrinsic excitability and synaptic transmission. These results suggest the contribution of PNNs to neuronal excitability and synaptic transmission depends on different time courses of ChABC digestion.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
ESI Research Field
NEUROSCIENCE & BEHAVIOR
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/355895
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,China
2.School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,NT, Hong Kong Special Administrative Region,China
3.The Pediatric Neurology,Shenzhen Children's Hospital,Shenzhen,518038,China
4.Brain Research Centre and Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China
Corresponding Author AffilicationDepartment of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Liu,Luping,Zhang,Yujie,Ju,Jun. Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time courses[J]. NEUROSCIENCE LETTERS,2022,785.
APA
Liu,Luping,Zhang,Yujie,&Ju,Jun.(2022).Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time courses.NEUROSCIENCE LETTERS,785.
MLA
Liu,Luping,et al."Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time courses".NEUROSCIENCE LETTERS 785(2022).
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