Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants

Li，Yaning1,7; Fan，Qing2,3; Zhou，Bing2,3; Shen，Yaping1; Zhang，Yuanyuan1; Cheng，Lin2,3; Qi，Furong2,3; Song，Shuo2,3; Guo，Yingying1; Yan，Renhong4; Ju，Bin2,3,5; Zhang，Zheng2,3,5,6

2022-06-17

10.1016/j.isci.2022.104431

ISCIENCE   Impact Factor & Quartile

2589-0042

The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.

SCI

English

Corresponding

National Science Fund for Distinguished Young Scholars[82025022] ; National Natural Science Foundation of China["92169204","82002140","82171752","82101861"] ; National Key Plan for Scientific Research and Development of China[2021YFC0864500] ; Guangdong Basic and Applied Basic Research Foundation["2021B1515020034","2021A1515011009"] ; Shenzhen Science and Technology Program[RCYX20200714114700046] ; Sci- ence and Technology Innovation Committee of Shenzhen Municipality["JSGG20200207155251653","JSGG20200807171401008","JSGG20210901145200002","KQTD20200909113758004"]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000828202700010

CELL PRESS

2-s2.0-85131947566

Web of Science

1.Center for Infectious Disease Research,Westlake Laboratory of Life Sciences and Biomedicine,Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,Zhejiang Province,Hangzhou,310024,China
2.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Guangdong Province,Shenzhen,518112,China
3.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Guangdong Province,Shenzhen,518112,China
4.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Guangdong Province,Shenzhen,518055,China
5.Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation,Guangdong Province,Shenzhen,518112,China
6.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Guangdong Province,Shenzhen,518112,China
7.Beijing Advanced Innovation Center for Structural Biology,Tsinghua-Peking Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing,100084,China

Li，Yaning,Fan，Qing,Zhou，Bing,et al. Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants[J]. ISCIENCE,2022,25(6).

Li，Yaning.,Fan，Qing.,Zhou，Bing.,Shen，Yaping.,Zhang，Yuanyuan.,...&Zhang，Zheng.(2022).Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants.ISCIENCE,25(6).

Li，Yaning,et al."Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants".ISCIENCE 25.6(2022).