中文版 | English
Title

ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules

Author
Corresponding AuthorQian,Weiqiang
Publication Years
2022-07-01
DOI
Source Title
ISSN
2055-026X
EISSN
2055-0278
Abstract
["High temperature is one of the major environmental stresses affecting plant growth and fitness. Heat stress transcription factors (HSFs) play critical roles in regulating the expression of heat-responsive genes. However, how HSFs are regulated remains obscure. Here, we show that ALBA4, ALBA5 and ALBA6, which phase separate into stress granules (SGs) and processing bodies (PBs) under heat stress, directly bind selected messenger RNAs, including HSF mRNAs, and recruit them into SGs and PBs to protect them from degradation under heat stress in Arabidopsis. The alba456 triple mutants, but not single and double mutants, display pleiotropic developmental defects and hypersensitivity to heat stress. Mutations in XRN4, a cytoplasmic 5 ' to 3 ' exoribonuclease, can rescue the observed developmental and heat-sensitive phenotypes of alba456 seedlings. Our study reveals a new layer of regulation for HSFs whereby HSF mRNAs are stabilized by redundant action of ALBA proteins in SGs and PBs for plant thermotolerance.","Heat stress transcription factors (HSFs) play critical roles in response to heat stress. This study reveals a new regulatory mechanism in Arabidospis by which ALBA proteins stabilize HSFs in cytoplasmic granules under heat stress."]
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
National Key R&D Programme of China[2018YFE0204700] ; National Natural Science Foundation of China["32170285","31970614"]
WOS Research Area
Plant Sciences
WOS Subject
Plant Sciences
WOS Accession No
WOS:000825060300002
Publisher
Scopus EID
2-s2.0-85133888326
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:5
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/355931
DepartmentSUSTech-Peking University National Institute of Plants and Food
生命科学学院
生命科学学院_生物系
Affiliation
1.State Key Laboratory of Protein and Plant Gene Research,Peking-Tsinghua Center for Life Sciences,School of Advanced Agricultural Sciences,Peking University,Beijing,China
2.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,Institute of Plant and Food Science,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China
3.School of Computing Sciences,University of East Anglia,Norwich,United Kingdom
4.School of Life Sciences,Peking University,Beijing,China
Recommended Citation
GB/T 7714
Tong,Jinjin,Ren,Zhitong,Sun,Linhua,et al. ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules[J]. Nature Plants,2022.
APA
Tong,Jinjin.,Ren,Zhitong.,Sun,Linhua.,Zhou,Sixian.,Yuan,Wei.,...&Qian,Weiqiang.(2022).ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules.Nature Plants.
MLA
Tong,Jinjin,et al."ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules".Nature Plants (2022).
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