Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes

Chen, Chi1; Bin Wang1; Zhang, Haojie1; Wang, Yuying1; Yu, Shiyan2; Zhou, Shuo3; Chen, Yi1; Xia, Fangzhen1; Zhai, Hualing1; Wang, Ningjian4; Lu, Yingli1

2022-07-01

10.1007/s12011-022-03357-6

BIOLOGICAL TRACE ELEMENT RESEARCH   Impact Factor & Quartile

0163-4984

1559-0720

We aimed to explore whether an elevated blood lead level (BLL) is associated with visceral adipose dysfunction in patients with type 2 diabetes mellitus (T2DM). Four thousand one hundred and fourteen diabetic participants were enrolled from seven communities in Shanghai in 2018 in the cross-sectional METAL study. BLL was measured by graphite furnace atomic absorption spectrometry. Visceral adiposity index (VAI) and lipid accumulation product (LAP)were calculated by simple anthropometric and biochemical parameters. We found that medians (IQR) of BLL were 26.0 mu g/L (18.0-37.0) for men and 25.0 mu g/L (18.0-35.0) for women, respectively. In men, each doubling of BLL was associated with a 2.0% higher VAI (95% CI, 0.6 to 3.5%) and 1.8% higher LAP (95% CI, 0.2 to 3.3%) after full adjustment. Using the lowest BLL quartile as the referent group, significant positive trends were observed for BLL with VAI and LAP. In women, each doubling of BLL was associated with a 1.9% higher LAP (95% CI, 0.6 to 3.1%). Additionally, there was a marginally significant positive association between BLL and VAI, either using log2-transformed concentrations as continuous variables or categorized in quartiles. In conclusion, lead exposure is associated with visceral adipose dysfunction in patients with T2DM. Further prospective studies are warranted to confirm our findings.

Lead Visceral adipose dysfunction Type 2 diabetes mellitus Epidemiology

SCI

English

Others

National Natural Science Foundation of China["82100846","82170870","82120108008"] ; Shanghai Sailing Program[20YF1423500] ; Science and Technology Commission of Shanghai Municipality[19140902400] ; Clinical Research Plan of SHDC[SHDC2020CR4006]

Biochemistry & Molecular Biology ; Endocrinology & Metabolism

Biochemistry & Molecular Biology ; Endocrinology & Metabolism

WOS:000826788000001

SPRINGERNATURE

BIOLOGY & BIOCHEMISTRY

2-s2.0-85134504345

Web of Science

1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst Precis Med, Sch Med, Shanghai, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Anesth, Shenzhen, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Endocrinol & Metab, Huangpu Branch,Sch Med, Shanghai, Peoples R China

Chen, Chi,Bin Wang,Zhang, Haojie,et al. Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2022,201(5):2266-2273.

Chen, Chi.,Bin Wang.,Zhang, Haojie.,Wang, Yuying.,Yu, Shiyan.,...&Lu, Yingli.(2022).Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes.BIOLOGICAL TRACE ELEMENT RESEARCH,201(5),2266-2273.

Chen, Chi,et al."Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes".BIOLOGICAL TRACE ELEMENT RESEARCH 201.5(2022):2266-2273.