中文版 | English
Title

Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment

Author
Corresponding AuthorShen, Ao; Xiang, Andy Peng; Zhang, Lingmin
Publication Years
2022-07-16
DOI
Source Title
EISSN
1477-3155
Volume20Issue:1
Abstract
["Background: Cytomegalovirus (CMV) pneumonia is a major cause of morbidity and mortality in immunodeficiency individuals, including transplant recipients and Acquired Immune Deficiency Syndrome patients. Antiviral drugs ganciclovir (GCV) and phosphonoformate (PFA) are first-line agents for pneumonia caused by herpesvirus infection. However, the therapy suffers from various limitations such as low efficiency, drug resistance, toxicity, and lack of specificity.","Methods: The antiviral drugs GCV and PFA were loaded into the pH-responsive nanoparticles fabricated by poly(lactic-co-glycolic acid) (ELGA) and 1,2-dioleoyl-3-trimethylammonium-propane (120TAP), and further coated with cell membranes derived from bone marrow mesenchymal stem cells to form artificial stem cells, namely MPDGP. We evaluated the viral suppression effects of MPDGP in vitro and in vivo.","Results: MPDGP showed significant inflammation tropism and efficient suppression of viral replication and virus infection-associated inflammation in the CMV-induced pneumonia model. The synergistic effects of the combination of viral DNA elongation inhibitor GCV and viral DNA polymerase inhibitor PFA on suppressing the inflammation efficiently.","Conclusion: The present study develops a novel therapeutic intervention using artificial stem cells to deliver antiviral drugs at inflammatory sites, which shows great potential for the targeted treatment of pneumonia. To our best knowledge, we are the first to fabricate this kind of artificial stem cell to deliver antiviral drugs for pneumonia treatment."]
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China["82070406","82072047","81870142","82170008","81700382"] ; Research Foundation of Education Bureau of Guangdong Province[2021ZDZX2004] ; Natural Science Foundation of Guangdong Province["2020A1515011158","2019A1515012166"] ; Basic and Applied Basic Research Project of Guangzhou[02080390]
WOS Research Area
Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS Subject
Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS Accession No
WOS:000826151000001
Publisher
EI Accession Number
20223012387428
EI Keywords
Bone ; Controlled drug delivery ; Diseases ; Pathology ; Stem cells ; Targeted drug delivery ; Viruses
ESI Classification Code
Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Scopus EID
2-s2.0-85134364631
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/356169
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Guangzhou Med Univ, Affiliated Hosp 3 & 5, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Peoples R China
2.Guangzhou Med Univ, Affiliated Hosp 3 & 5, Sch Pharmaceut Sci, NMPA Key Lab Resp Dis, Guangzhou 511436, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Ctr Stem Cell Biol & Tissue Engn, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China
Recommended Citation
GB/T 7714
Qin, Aiping,Chen, Sheng,Li, Songpei,et al. Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment[J]. JOURNAL OF NANOBIOTECHNOLOGY,2022,20(1).
APA
Qin, Aiping.,Chen, Sheng.,Li, Songpei.,Li, Qizhen.,Huang, Xiaotao.,...&Zhang, Lingmin.(2022).Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment.JOURNAL OF NANOBIOTECHNOLOGY,20(1).
MLA
Qin, Aiping,et al."Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment".JOURNAL OF NANOBIOTECHNOLOGY 20.1(2022).
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