Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment

Qin, Aiping1,2; Chen, Sheng1,2; Li, Songpei1,2; Li, Qizhen3; Huang, Xiaotao1,2; Xia, Luoxing1,2; Lin, Yinshan1,2; Shen, Ao1,2; Xiang, Andy Peng4; Zhang, Lingmin1,2

2022-07-16

10.1186/s12951-022-01547-x

JOURNAL OF NANOBIOTECHNOLOGY   Impact Factor & Quartile

1477-3155

["Background: Cytomegalovirus (CMV) pneumonia is a major cause of morbidity and mortality in immunodeficiency individuals, including transplant recipients and Acquired Immune Deficiency Syndrome patients. Antiviral drugs ganciclovir (GCV) and phosphonoformate (PFA) are first-line agents for pneumonia caused by herpesvirus infection. However, the therapy suffers from various limitations such as low efficiency, drug resistance, toxicity, and lack of specificity.","Methods: The antiviral drugs GCV and PFA were loaded into the pH-responsive nanoparticles fabricated by poly(lactic-co-glycolic acid) (ELGA) and 1,2-dioleoyl-3-trimethylammonium-propane (120TAP), and further coated with cell membranes derived from bone marrow mesenchymal stem cells to form artificial stem cells, namely MPDGP. We evaluated the viral suppression effects of MPDGP in vitro and in vivo.","Results: MPDGP showed significant inflammation tropism and efficient suppression of viral replication and virus infection-associated inflammation in the CMV-induced pneumonia model. The synergistic effects of the combination of viral DNA elongation inhibitor GCV and viral DNA polymerase inhibitor PFA on suppressing the inflammation efficiently.","Conclusion: The present study develops a novel therapeutic intervention using artificial stem cells to deliver antiviral drugs at inflammatory sites, which shows great potential for the targeted treatment of pneumonia. To our best knowledge, we are the first to fabricate this kind of artificial stem cell to deliver antiviral drugs for pneumonia treatment."]

Artificial stem cells Inflammation-tropic delivery Pneumonia Cytomegalovirus Antiviral drugs

SCI ; EI

English

Others

National Natural Science Foundation of China["82070406","82072047","81870142","82170008","81700382"] ; Research Foundation of Education Bureau of Guangdong Province[2021ZDZX2004] ; Natural Science Foundation of Guangdong Province["2020A1515011158","2019A1515012166"] ; Basic and Applied Basic Research Project of Guangzhou[02080390]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology

WOS:000826151000001

BMC

20223012387428

Bone ; Controlled drug delivery ; Diseases ; Pathology ; Stem cells ; Targeted drug delivery ; Viruses

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9

BIOLOGY & BIOCHEMISTRY

2-s2.0-85134364631

Web of Science

1.Guangzhou Med Univ, Affiliated Hosp 3 & 5, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Peoples R China
2.Guangzhou Med Univ, Affiliated Hosp 3 & 5, Sch Pharmaceut Sci, NMPA Key Lab Resp Dis, Guangzhou 511436, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Ctr Stem Cell Biol & Tissue Engn, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China

Qin, Aiping,Chen, Sheng,Li, Songpei,et al. Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment[J]. JOURNAL OF NANOBIOTECHNOLOGY,2022,20(1).

Qin, Aiping.,Chen, Sheng.,Li, Songpei.,Li, Qizhen.,Huang, Xiaotao.,...&Zhang, Lingmin.(2022).Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment.JOURNAL OF NANOBIOTECHNOLOGY,20(1).

Qin, Aiping,et al."Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment".JOURNAL OF NANOBIOTECHNOLOGY 20.1(2022).