中文版 | English
Title

Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles

Author
Corresponding AuthorLi Pengfei; Qi Yunkun; Li Wenjun
Publication Years
2022-03-08
DOI
Source Title
ISSN
0253-2786
Volume42Issue:6Pages:1722-1734
Abstract

A chiral phosphoric acid catalyzed aza-1,8-conjugate addition of isoxazol-5(4H)-ones to 6-methylene-6H-indoles formed in situ from 6-indolylmethanols has been developed for the first time. Notably, the remote stereocontrolled 1,8-addition of isoxazol-5(4H)-ones was featured by N-selectivity, affording aza-adducts in 70%similar to 83% yields with 61%similar to 96% ee.

Keywords
URL[Source Record]
Indexed By
Language
Chinese
SUSTech Authorship
Corresponding
Funding Project
Natural Science Foundation of Shandong Province[ZR2021MB026] ; Special Funds of the Taishan Scholar Program of Shandong Province[tsqn201812047] ; Shenzhen Innovation of Science and Technology Commission[20200925151614002] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Organic
WOS Accession No
WOS:000826720300013
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/356202
DepartmentShenzhen Grubbs Institute
理学院_化学系
Affiliation
1.Qingdao Univ, Sch Pharm, Qingdao 266073, Shandong, Peoples R China
2.South Univ Sci & Technol China, Coll Sci, Shenzhen Grubbs Inst, Guangzhou 518055, Peoples R China
3.South Univ Sci & Technol China, Coll Sci, Dept Chem, Guangdong Prov Key Lab Catalysis, Guangzhou 518055, Peoples R China
Corresponding Author AffilicationShenzhen Grubbs Institute;  Department of Chemistry
Recommended Citation
GB/T 7714
Wang Xing,Song Qianqian,Chen Xuling,et al. Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2022,42(6):1722-1734.
APA
Wang Xing,Song Qianqian,Chen Xuling,Li Pengfei,Qi Yunkun,&Li Wenjun.(2022).Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles.CHINESE JOURNAL OF ORGANIC CHEMISTRY,42(6),1722-1734.
MLA
Wang Xing,et al."Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles".CHINESE JOURNAL OF ORGANIC CHEMISTRY 42.6(2022):1722-1734.
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