| Title | Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles |
| Author | |
| Corresponding Author | Li Pengfei; Qi Yunkun; Li Wenjun |
| Publication Years | 2022-03-08
|
| DOI | |
| Source Title | |
| ISSN | 0253-2786
|
| Volume | 42Issue:6Pages:1722-1734 |
| Abstract | A chiral phosphoric acid catalyzed aza-1,8-conjugate addition of isoxazol-5(4H)-ones to 6-methylene-6H-indoles formed in situ from 6-indolylmethanols has been developed for the first time. Notably, the remote stereocontrolled 1,8-addition of isoxazol-5(4H)-ones was featured by N-selectivity, affording aza-adducts in 70%similar to 83% yields with 61%similar to 96% ee. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | Chinese
|
| SUSTech Authorship | Corresponding
|
| Funding Project | Natural Science Foundation of Shandong Province[ZR2021MB026]
; Special Funds of the Taishan Scholar Program of Shandong Province[tsqn201812047]
; Shenzhen Innovation of Science and Technology Commission[20200925151614002]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000826720300013
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/356202 |
| Department | Shenzhen Grubbs Institute 理学院_化学系 |
| Affiliation | 1.Qingdao Univ, Sch Pharm, Qingdao 266073, Shandong, Peoples R China 2.South Univ Sci & Technol China, Coll Sci, Shenzhen Grubbs Inst, Guangzhou 518055, Peoples R China 3.South Univ Sci & Technol China, Coll Sci, Dept Chem, Guangdong Prov Key Lab Catalysis, Guangzhou 518055, Peoples R China |
| Corresponding Author Affilication | Shenzhen Grubbs Institute; Department of Chemistry |
| Recommended Citation GB/T 7714 |
Wang Xing,Song Qianqian,Chen Xuling,et al. Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2022,42(6):1722-1734.
|
| APA |
Wang Xing,Song Qianqian,Chen Xuling,Li Pengfei,Qi Yunkun,&Li Wenjun.(2022).Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles.CHINESE JOURNAL OF ORGANIC CHEMISTRY,42(6),1722-1734.
|
| MLA |
Wang Xing,et al."Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles".CHINESE JOURNAL OF ORGANIC CHEMISTRY 42.6(2022):1722-1734.
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
;
Edit Comment