| Title | MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss |
| Author | Chen, Zhihao1,2,7; Huai, Ying1,2; Chen, Gaoyang3; Liu, Shuyu1,2; Zhang, Yan1,2,4,5; Li, Dijie1,2,6; Zhao, Fan1,2,4,5; Chen, Xiaofeng4,5; Mao, Wenjing1,2; Wang, Xuehao1,2; Yin, Chong1,2; Yang, Chaofei1,2; Xu, Xia1,2; Ru, Kang1,2; Deng, Xiaoni1,2; Hu, Lifang1,2; Li, Yu1,2; Peng, Songlin3  ; Zhang, Ge6; Lin, Xiao1,2; Qian, Airong1,2
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| Corresponding Author | Peng, Songlin; Zhang, Ge; Lin, Xiao; Qian, Airong |
| Publication Years | 2022
|
| DOI | |
| Source Title | |
| ISSN | 1449-2288
|
| Volume | 18Issue:13 |
| Abstract | Senile osteoporosis is one of the major health problems in an aging society. Decreased bone formation due to osteoblast dysfunction may be one of the causes of aging-related bone loss. With increasing evidence suggesting that multiple microRNAs (miRNAs) play important roles in osteoblast function, the relationship between miRNAs and senile osteoporosis has become a popular research topic. Previously, we confirmed that mechanoresponsive miR-138-5p negatively regulated bone anabolic action. In this study, the miR-138-5p level was found to be negatively correlated with BMD and osteogenic markers in bone specimens of senile osteoporotic patients by bioinformatic analysis and experimental verification. Furthermore, high miR-138-5p levels aggravated the decrease of aged osteoblast differentiation in vitro and led to worse bone loss in aged osteoblastic miR-138-5p transgenic mice in vivo. We also previously identified that the target of miR-138-5p, microtubule actin cross-linking factor 1 (MACF1), could attenuate senile osteoporosis. Here, miR-138-5p was demonstrated to regulate aged osteoblast differentiation by targeting MACF1. Finally, the therapeutic inhibition of miR-138-5p counteracted the decrease in bone formation and aging-related bone loss in aged mice. Overall, our results highlight the crucial roles and the molecular mechanism of miR-138-5p in aging-related bone loss and may provide a powerful therapeutic target for ameliorating senile osteoporosis. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | Natural Science Foundation of China["32101055","82072106","31570940","81872129","81700784","81772017"]
; China Postdoctoral Science Foundation["2020M683573","2017M613196"]
; Natural Science Basic Research Plan in Shaanxi Province of China["2021JQ-128","2018JM3040"]
; Shaanxi Provincial Key RD Program["2018KWZ-10","2021SF-242"]
; Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University[CX201821]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Life Sciences & Biomedicine - Other Topics
|
| WOS Subject | Biochemistry & Molecular Biology
; Biology
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| WOS Accession No | WOS:000829372300003
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/359436 |
| Department | School of Medicine 南方科技大学第一附属医院 |
| Affiliation | 1.Northwestern Polytech Univ, Lab Bone Metab, Xian Key Lab Special Med & Hlth Engn, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China 2.Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Res Ctr Special Med & Hlth Syst Engn, NPU UAB Joint Lab Bone Metab,Sch Life Sci, Xian 710072, Shaanxi, Peoples R China 3.Jinan Univ, Sch Med, Southern Univ Sci & Technol, Dept Spine Surg,Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China 4.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China 5.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Mol Genet, Xian 710049, Shaanxi, Peoples R China 6.Hong Kong Baptist Univ, Sch Chinese Med, Law Sau Fai Inst Adv Translat Med Bone & Joint Di, Hong Kong 999077, Peoples R China 7.Fourth Mil Med Univ, Xijing Hosp, Dept Gynaecol & Obstet, Xian 710032, Shaanxi, Peoples R China |
| Corresponding Author Affilication | School of Medicine; Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Chen, Zhihao,Huai, Ying,Chen, Gaoyang,et al. MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss[J]. International Journal of Biological Sciences,2022,18(13).
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| APA |
Chen, Zhihao.,Huai, Ying.,Chen, Gaoyang.,Liu, Shuyu.,Zhang, Yan.,...&Qian, Airong.(2022).MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss.International Journal of Biological Sciences,18(13).
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| MLA |
Chen, Zhihao,et al."MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss".International Journal of Biological Sciences 18.13(2022).
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