A novel cascaded energy conversion system inducing efficient and precise cancer therapy

Kang, Yong3; Kong, Na1,2; Ou, Meitong4; Wang, Ying4; Xiao, Qicai4; Mei, Lin4; Liu, Bing5; Chen, Liqun3; Zeng, Xiaobin1,2; Ji, Xiaoyuan3

2023-02-01

10.1016/j.bioactmat.2022.07.007

BIOACTIVE MATERIALS   Impact Factor & Quartile

2452-199X

Cancer therapies based on energy conversion, such as photothermal therapy (PTT, light-to-thermal energy conversion) and photodynamic therapy (PDT, light-to-chemical energy conversion) have attracted extensive attention in preclinical research. However, the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied light prevent further advanced clinical practices. Here, we developed a thermoelectric therapy (TET) based on thermoelectric materials constructed p-n heterojunction (SrTiO3/Cu2Se nanoplates) on the principle of light-thermal-electricity-chemical energy conversion. Upon irradiation and natural cooling-induced the temperature gradient (35-45 degrees C), a self-build-in electric field was constructed and thereby facilitated charges separation in bulk SrTiO3 and Cu2Se. Importantly, the contact between SrTiO3 (n type) and Cu2Se (p type) constructed another interfacial electric field, further guiding the separated charges to re-locate onto the surfaces of SrTiO3 and Cu2Se. The formation of two electric fields minimized probability of charges recombination. Of note, high-performance superoxide radicals and hydroxyl radicals' generation from O-2 and H2O under catalyzation by separated electrons and holes, led to intracellular ROS burst and cancer cells apoptosis without apparent damage to surrounding tissues. Construction of bulk and interfacial electric fields in heterojunction for improving charges separation and transfer is also expected to provide a robust strategy for diverse applications.

Thermoelectric therapy Photothermal therapy Reactive oxygen species p-n heterojunction Energy conversion

SCI

English

Corresponding

National Natural Science Founda- tion of China["32122044","32071322","32000815"] ; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20210324113004010","RCBS20200714114855313"]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000829599400001

KEAI PUBLISHING LTD

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Ctr Lab Longhua Branch,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Infect Dis,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
3.Tianjin Univ, Acad Med Engn & Translat Med, Med Coll, Tianjin 300072, Peoples R China
4.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Peoples R China
5.Rocket Force Characterist Med Ctr, Dept Dis Control & Prevent, 16 Xinjiekouwai St, Beijing 100088, Peoples R China

Kang, Yong,Kong, Na,Ou, Meitong,et al. A novel cascaded energy conversion system inducing efficient and precise cancer therapy[J]. BIOACTIVE MATERIALS,2023,20.

Kang, Yong.,Kong, Na.,Ou, Meitong.,Wang, Ying.,Xiao, Qicai.,...&Ji, Xiaoyuan.(2023).A novel cascaded energy conversion system inducing efficient and precise cancer therapy.BIOACTIVE MATERIALS,20.

Kang, Yong,et al."A novel cascaded energy conversion system inducing efficient and precise cancer therapy".BIOACTIVE MATERIALS 20(2023).