中文版 | English
Title

A novel cascaded energy conversion system inducing efficient and precise cancer therapy

Author
Corresponding AuthorChen, Liqun; Zeng, Xiaobin; Ji, Xiaoyuan
Publication Years
2023-02-01
DOI
Source Title
EISSN
2452-199X
Volume20
Abstract
Cancer therapies based on energy conversion, such as photothermal therapy (PTT, light-to-thermal energy conversion) and photodynamic therapy (PDT, light-to-chemical energy conversion) have attracted extensive attention in preclinical research. However, the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied light prevent further advanced clinical practices. Here, we developed a thermoelectric therapy (TET) based on thermoelectric materials constructed p-n heterojunction (SrTiO3/Cu2Se nanoplates) on the principle of light-thermal-electricity-chemical energy conversion. Upon irradiation and natural cooling-induced the temperature gradient (35-45 degrees C), a self-build-in electric field was constructed and thereby facilitated charges separation in bulk SrTiO3 and Cu2Se. Importantly, the contact between SrTiO3 (n type) and Cu2Se (p type) constructed another interfacial electric field, further guiding the separated charges to re-locate onto the surfaces of SrTiO3 and Cu2Se. The formation of two electric fields minimized probability of charges recombination. Of note, high-performance superoxide radicals and hydroxyl radicals' generation from O-2 and H2O under catalyzation by separated electrons and holes, led to intracellular ROS burst and cancer cells apoptosis without apparent damage to surrounding tissues. Construction of bulk and interfacial electric fields in heterojunction for improving charges separation and transfer is also expected to provide a robust strategy for diverse applications.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Founda- tion of China["32122044","32071322","32000815"] ; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20210324113004010","RCBS20200714114855313"]
WOS Research Area
Engineering ; Materials Science
WOS Subject
Engineering, Biomedical ; Materials Science, Biomaterials
WOS Accession No
WOS:000829599400001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttps://kc.sustech.edu.cn/handle/2SGJ60CL/359445
DepartmentShenzhen People's Hospital
工学院_机械与能源工程系
理学院_数学系
理学院_地球与空间科学系
理学院_化学系
深圳格拉布斯研究院
工学院_材料科学与工程系
Affiliation
1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Ctr Lab Longhua Branch,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Infect Dis,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
3.Tianjin Univ, Acad Med Engn & Translat Med, Med Coll, Tianjin 300072, Peoples R China
4.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Peoples R China
5.Rocket Force Characterist Med Ctr, Dept Dis Control & Prevent, 16 Xinjiekouwai St, Beijing 100088, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Kang, Yong,Kong, Na,Ou, Meitong,et al. A novel cascaded energy conversion system inducing efficient and precise cancer therapy[J]. BIOACTIVE MATERIALS,2023,20.
APA
Kang, Yong.,Kong, Na.,Ou, Meitong.,Wang, Ying.,Xiao, Qicai.,...&Ji, Xiaoyuan.(2023).A novel cascaded energy conversion system inducing efficient and precise cancer therapy.BIOACTIVE MATERIALS,20.
MLA
Kang, Yong,et al."A novel cascaded energy conversion system inducing efficient and precise cancer therapy".BIOACTIVE MATERIALS 20(2023).
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