| Title | Systematic characterisation of the effective components of five Callicarpa species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity |
| Author | |
| Corresponding Author | Feng, Shixiu; Yi, Bo |
| Publication Years | 2022-07-01
|
| DOI | |
| Source Title | |
| ISSN | 1478-6419
|
| EISSN | 1478-6427
|
| Abstract | Callicarpa kwangtungensis (C. Kw), C. macrophylla (C. Ma), C. nudiflora (C. Nu), C. formosana (C. Fo), and C. kochiana (C. Ko) were medicinal plant resource in China. In this study, the UPLC/Q-TOF-MS analysis was performed and 151 compounds were identified. PCA analysis metabolic profiles of C. Nu, C. Ko and C. Kw leaves differ significantly from the other two Callicarpa species, while C. Fo and C. Ma share similar chemical constituents. OPLS-DA highlight with an S-plot indicated that there are 14 robust known chemical markers enabling the differentiation between these five Callicarpa plants. C. Ma, C. Nu, and C. Fo leaves extracts treatment effectively reversed the body weight loss, uric acid and creatinine content, hepatic XOD activity, kidney, liver, and ankle tissues injury and inflammation induced by potassium oxonate in hyperuricemia mice. While Ko and C. Kw leaves extracts treatment showed less improvement in hyperuricemia mice. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | Key Research & Development Plan of Hainan Province[ZDYF2018228]
; Urban Administration and Law Enforcement Bureau of Shenzhen Municipality Research Program[202206]
; Key Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibetan Plateau in Qinghai Province[2020ZJ-Y40]
|
| WOS Research Area | Chemistry
; Pharmacology & Pharmacy
|
| WOS Subject | Chemistry, Applied
; Chemistry, Medicinal
|
| WOS Accession No | WOS:000829316800001
|
| Publisher | |
| ESI Research Field | PHARMACOLOGY & TOXICOLOGY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/359479 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Fairylake Bot Garden, Shenzhen, Peoples R China 2.Chinese Acad Sci, Key Lab South Subtrop Plant Divers, Shenzhen, Peoples R China 3.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Gastroenterol, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 5.Qinghai Normal Univ, Coll Life Sci, Xining, Peoples R China 6.928th Hosp PLA Joint Logist Support Force, Dept Pharm, Haikou, Hainan, Peoples R China |
| Recommended Citation GB/T 7714 |
Feng, Shixiu,Wang, Luolin,Deng, Li,et al. Systematic characterisation of the effective components of five Callicarpa species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity[J]. NATURAL PRODUCT RESEARCH,2022.
|
| APA |
Feng, Shixiu.,Wang, Luolin.,Deng, Li.,Zhang, Min.,Ma, Wenyu.,...&Yi, Bo.(2022).Systematic characterisation of the effective components of five Callicarpa species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity.NATURAL PRODUCT RESEARCH.
|
| MLA |
Feng, Shixiu,et al."Systematic characterisation of the effective components of five Callicarpa species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity".NATURAL PRODUCT RESEARCH (2022).
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