Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Li, De-feng1; Yang, Mei-feng2; Xu, Hao-ming3; Zhu, Min-zheng3; Zhang, Yuan4; Tian, Cheng-mei5; Nie, Yu-qiang3; Wang, Jian-yao6; Liang, Yu-jie7; Yao, Jun1; Wang, Li-sheng1

2022-07-01

10.1039/d2tb01190e

Journal of Materials Chemistry B   Impact Factor & Quartile

2050-750X

2050-7518

As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral administration is critical for the treatment of IBD. Unfortunately, it is difficult to target the bowel located in the GI tract due to multiple physical barriers. The unique physicochemical properties of nanoparticle-based drug delivery systems (DDSs) and their enhanced permeability and retention effects in the inflamed bowel, render nanomedicines to be used to implement precise drug delivery at diseased sites in IBD therapy. In this review, we described the pathophysiological features of IBD, and designed strategies to exploit these features for intestinal targeting. In addition, we introduced the types of currently developed nano-targeted carriers, including synthetic nanoparticle-based and emerging naturally derived nanoparticles (e.g., extracellular vesicles and plant-derived nanoparticles). Moreover, recent developments in targeted oral nanoparticles for IBD therapy were also highlighted. Finally, we presented challenges associated with nanotechnology and potential directions for future IBD treatment.

SCI

English

First ; Corresponding

Natural Science Foundation of Guangdong Province[2018A0303100024] ; Technical Research and Development Project of Shenzhen["JCYJ2015 0403101028164","JCYC20170307100911479","JCYJ2019 0807145617113","JCYJ20210324113802006"] ; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK042] ; National Natural Science Foundation of China[81800489]

Materials Science

Materials Science, Biomaterials

WOS:000829457100001

ROYAL SOC CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Gastro, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
2.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen 518020, Guangdong, Peoples R China
3.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou 510030, Peoples R China
4.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou 516000, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Emerge, Shenzhen 518020, Guangdong, Peoples R China
6.Shenzhen Childrens Hosp, Dept Gen Surg, 7019 Yitian Rd, Shenzhen 518026, Guangdong, Peoples R China
7.Shenzhen Kangning Hosp, 1080 Cuizu Rd, Shenzhen 518020, Guangdong, Peoples R China

Li, De-feng,Yang, Mei-feng,Xu, Hao-ming,et al. Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease[J]. Journal of Materials Chemistry B,2022.

Li, De-feng.,Yang, Mei-feng.,Xu, Hao-ming.,Zhu, Min-zheng.,Zhang, Yuan.,...&Wang, Li-sheng.(2022).Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease.Journal of Materials Chemistry B.

Li, De-feng,et al."Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease".Journal of Materials Chemistry B (2022).