Reactive Oxygen Species Scavenging Functional Hydrogel Delivers Procyanidins for the Treatment of Traumatic Brain Injury in Mice

Huang, Xuyang1,2; Ye, Yongqing1,2; Zhang, Jianyong1; Zhang, Xuefeng2; Ma, Hongwei2; Zhang, Yongkang2; Fu, Xianhua1; Tang, JiaJia1; Jiang, Ning4; Han, Yuhan1; Liu, Hongmei3; Chen, Honglin1

2022-07-01

10.1021/acsami.2c04930

ACS Applied Materials & Interfaces   Impact Factor & Quartile

1944-8244

1944-8252

Traumatic brain injury (TBI) is accompanied by the overload of reactive oxygen species (ROS), which can result in secondary brain injury. Although procyanidins (PCs) have a powerful free radical scavenging capability and have been widely studied in the treatment of TBI, conventional systemic drug therapy cannot make the drug reach the targeted area in the early stage of TBI and will cause systemic side effects because of the presence of the blood-brain barrier (BBB). To address this tissue, we designed and fabricated a ROS-scavenging functional hydrogel loaded PC (GelMA-PPS/PC) to deliver the drug by responding to the traumatic microenvironment. In situ injection of the GelMAPPS/PC hydrogel effectively avoided the BBB and was directly applied to the surface of brain tissue to target the traumatic area. Hydrophobic poly(propylene sulfide)(60) (PPS60), an ROS quencher and H2O2-responsive substance, was covalently bound to GelMA and exposed in response to the trauma microenvironment. At the same time, the H(2)O(2 )response of PPS60 further caused the structure of the hydrogel to degrade and release the encapsulated PC. Then PC could regulate the oxidative stress response in the cells and synergistically deplete ROS to play a neurotrophic protective role. This work suggests a novel method for the treatment of secondary brain injury by inhibiting the oxidative stress response after TBI.

functional hydrogel procyanidins ROS scavenger brain protection traumatic brain injury

SCI ; EI

English

Corresponding

Jiangsu Depart-ment of Science and Technology[BE2020647] ; Social Development Project of Medical Research Project of Jiangsu Provincial Health Commission[M2020081] ; Social Development Project of Xuzhou Department of Science and Technology[KC20079] ; Suqian Sci Tech Program[K202104] ; Science and Technology Development Fund of Nanjing Medical University[NMU20210294]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000830029600001

AMER CHEMICAL SOC

20223312565470

Brain ; Controlled drug delivery ; Flavonoids ; Free radicals ; Hydrogels ; Mammals ; Microcomputers ; Sulfur compounds ; Targeted drug delivery ; Tissue

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Digital Computers and Systems:722.4 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1

Web of Science

1.Jiangsu Univ, Xuzhou Med Univ, Dept Neurosurg, Suqian Clin Coll, Suqian 223800, Peoples R China
2.Xuzhou Med Univ, Inst Nervous Syst Dis, Xuzhou 221002, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Jiangsu Univ, Xuzhou Med Univ, Peoples China, Suqian Clin Coll, Suqian 223800, Peoples R China

Huang, Xuyang,Ye, Yongqing,Zhang, Jianyong,et al. Reactive Oxygen Species Scavenging Functional Hydrogel Delivers Procyanidins for the Treatment of Traumatic Brain Injury in Mice[J]. ACS Applied Materials & Interfaces,2022.

Huang, Xuyang.,Ye, Yongqing.,Zhang, Jianyong.,Zhang, Xuefeng.,Ma, Hongwei.,...&Chen, Honglin.(2022).Reactive Oxygen Species Scavenging Functional Hydrogel Delivers Procyanidins for the Treatment of Traumatic Brain Injury in Mice.ACS Applied Materials & Interfaces.

Huang, Xuyang,et al."Reactive Oxygen Species Scavenging Functional Hydrogel Delivers Procyanidins for the Treatment of Traumatic Brain Injury in Mice".ACS Applied Materials & Interfaces (2022).