Enantioselective Cu-catalyzed double hydroboration of alkynes to access chiral gem-diborylalkanes
|Corresponding Author||Yu，Peiyuan; Song，Qiuling|
Chiral organoborons are of great value in asymmetric synthesis, functional materials, and medicinal chemistry. The development of chiral bis(boryl) alkanes, especially optically enriched 1,1-diboron compounds, has been greatly inhibited by the lack of direct synthetic protocols. Therefore, it is very challenging to develop a simple and effective strategy to obtain chiral 1,1-diborylalkanes. Herein, we develop an enantioselective copper-catalyzed cascade double hydroboration of terminal alkynes and highly enantioenriched gem-diborylalkanes were readily obtained. Our strategy uses simple terminal alkynes and two different boranes to construct valuable chiral gem-bis(boryl) alkanes with one catalytic and one ligand pattern, which represents the simplest and most straightforward strategy for constructing such chiral gem-diborons.
NI Journal Papers
National Outstanding Youth Science Fund Project of National Natural Science Foundation of China;National Outstanding Youth Science Fund Project of National Natural Science Foundation of China;
|WOS Accession No|
Cited Times [WOS]:8
|Document Type||Journal Article|
|Department||Department of Chemistry|
1.Institute of Next Generation Matter Transformation,College of Material Sciences Engineering,Huaqiao University,Xiamen,Fujian,361021,China
2.Department of Chemistry and Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen,518055,China
3.School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan,453007,China
4.State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin,China
|Corresponding Author Affilication||Department of Chemistry; Shenzhen Grubbs Institute|
Jin，Shengnan,Li，Jinxia,Liu，Kang,et al. Enantioselective Cu-catalyzed double hydroboration of alkynes to access chiral gem-diborylalkanes[J]. Nature Communications,2022,13(1).
Jin，Shengnan.,Li，Jinxia.,Liu，Kang.,Ding，Wei Yi.,Wang，Shuai.,...&Song，Qiuling.(2022).Enantioselective Cu-catalyzed double hydroboration of alkynes to access chiral gem-diborylalkanes.Nature Communications,13(1).
Jin，Shengnan,et al."Enantioselective Cu-catalyzed double hydroboration of alkynes to access chiral gem-diborylalkanes".Nature Communications 13.1(2022).
|Files in This Item:||There are no files associated with this item.|
|Recommend this item|
|Export to Endnote|
|Export to Excel|
|Export to Csv|
|Similar articles in Google Scholar|
|Similar articles in Baidu Scholar|
|Similar articles in Bing Scholar|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.