Ultrafast construction of partially hydrogen-bonded metal-hyaluronan networks with multiple biotissue-related features

Sun，Zhifang1; Lyu，Fucong2; Wu，Shaofei2; Lu，Zhouguang2; Cheng，Hua2

2022-11-01

10.1016/j.carbpol.2022.119852

CARBOHYDRATE POLYMERS   Impact Factor & Quartile

0144-8617

This paper reports a versatile and dynamic hydrogel system based on ultrafast coordination between partially hydrogen-bonded (PHB) biopolymer hyaluronic acid and a series of transition metal ions at appropriate pH values. It was found that the procedure for the hydrogel synthesis was extremely facile, requiring a simple mixing of the components within 2 s. The hydrogels exhibited high water content, up to 96 %. Even so, the hydrogels can be stretched >50 times and rapidly self-heal from damage within only 10 s without using any healing agents or heating. Furthermore, this dynamic hydrogel network underwent reversible sol-gel transitions as response to multiple disparate stimuli, including pH, temperature, ions, redox, and light. The photo-patterning ability of the hydrogel with a rapid gel-sol transition upon exposure to light was also demonstrated. We disclosed the principle and methodology to use PHB metal-biopolymer systems for constructing dynamic bio-related soft matters.

Dynamic network Hyaluronic acid Hydrogel Partial hydrogen bonding Self-healing

EI

English

Corresponding

National Natural Science Foundation of China[21875097];National Natural Science Foundation of China[21905002];

20223012400394

Biomolecules ; Biopolymers ; Hyaluronic acid ; Hydrogels ; Hydrogen ; Metal ions ; Organic acids ; Self-healing materials ; Sol-gels ; Transition metal compounds ; Transition metals

Metals, Plastics, Wood and Other Structural Materials:415 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Metallurgy and Metallography:531 ; Metallurgy:531.1 ; Biochemistry:801.2 ; Colloid Chemistry:801.3 ; Physical Chemistry:801.4 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Polymeric Materials:815.1

CHEMISTRY

2-s2.0-85134492397

Scopus

1.School of Chemistry and Chemical Engineering,Anyang Normal University,Anyang,Anyang,455000,China
2.Department of Materials Science and Engineering,Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials,Southern University of Science and Technology,Shenzhen,518055,China

Sun，Zhifang,Lyu，Fucong,Wu，Shaofei,et al. Ultrafast construction of partially hydrogen-bonded metal-hyaluronan networks with multiple biotissue-related features[J]. CARBOHYDRATE POLYMERS,2022,295.

Sun，Zhifang,Lyu，Fucong,Wu，Shaofei,Lu，Zhouguang,&Cheng，Hua.(2022).Ultrafast construction of partially hydrogen-bonded metal-hyaluronan networks with multiple biotissue-related features.CARBOHYDRATE POLYMERS,295.

Sun，Zhifang,et al."Ultrafast construction of partially hydrogen-bonded metal-hyaluronan networks with multiple biotissue-related features".CARBOHYDRATE POLYMERS 295(2022).