中文版 | English
Title

Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency

Author
Corresponding AuthorSingh,Parbeen; Tyagi,Deependra
Publication Years
2022-09-15
DOI
Source Title
ISSN
0254-0584
EISSN
1879-3312
Volume289
Abstract
The off-target payload delivery of γ-cyclodextrin metal organic framework (γ-CD-MOF) does not meet the requirements for targeted drug delivery applications. Herein, we synthesized γ-CD-MOF and crosslinked γ-CD-MOF (CL-γ-CD-MOF) to obtain the different sizes and different types of γ-CD-MOF. Furthermore, a simple post-modification method was applied to obtain the biofunctionalized γ-CD-MOFs to improve cellular interaction through hyaluronic acid (HA) for the first time. Various methods including measurement of different size of γ-CD-MOF, CL-γ-CD-MOF, and surface modified γ-CD-MOFs, followed by the characterization by various analytical techniques, drug absorption, cell viability, and cellular uptake studies, were performed to determine the functionality of the studied γ-CD-MOF-HA systems. The conjugation of γ-CD-MOF with HA (γ-CD-MOF-HA) showed a 4.8% higher average drug loading capacity than the γ-CD-MOF. It was found that the γ-CD-MOF-HA showed pH-responsive drug release and enhanced the cellular uptake of Doxorubicin (Dox) in HeLa cells. The present study results indicate the efficacy of the γ-CD-MOF-HA as a nano carrier, enabling a new direction for γ-CD-MOF to target the different tissues and cells.
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Corresponding
Funding Project
Shenzhen Polytechnic[6019330006K];Shenzhen Polytechnic[6019330007K];
WOS Research Area
Materials Science
WOS Subject
Materials Science, Multidisciplinary
WOS Accession No
WOS:000839349900003
Publisher
EI Accession Number
20223012393203
EI Keywords
Controlled drug delivery ; Hyaluronic acid ; Lanthanum compounds ; Metal-Organic Frameworks ; Metals ; Organic acids ; Targeted drug delivery
ESI Classification Code
Metallurgy:531.1 ; Organic Compounds:804.1
ESI Research Field
MATERIALS SCIENCE
Scopus EID
2-s2.0-85134425078
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/359532
DepartmentSchool of Medicine
Affiliation
1.Postdoctoral Innovation Practice Base,Shenzhen Polytechnic,Shenzhen,518055,China
2.Department of Molecular and Cell Biology,University of Connecticut,United States
3.Department of Chemistry,University of Connecticut,United States
4.School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China
5.Department of Mechanical Engineering,University of Connecticut,United States
Corresponding Author AffilicationSchool of Medicine
Recommended Citation
GB/T 7714
Singh,Parbeen,Feng,Jinglong,Golla,Vinaya Kumar,et al. Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,289.
APA
Singh,Parbeen,Feng,Jinglong,Golla,Vinaya Kumar,Lotfi,Ali,&Tyagi,Deependra.(2022).Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency.MATERIALS CHEMISTRY AND PHYSICS,289.
MLA
Singh,Parbeen,et al."Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency".MATERIALS CHEMISTRY AND PHYSICS 289(2022).
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