Title | Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency |
Author | |
Corresponding Author | Singh,Parbeen; Tyagi,Deependra |
Publication Years | 2022-09-15
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DOI | |
Source Title | |
ISSN | 0254-0584
|
EISSN | 1879-3312
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Volume | 289 |
Abstract | The off-target payload delivery of γ-cyclodextrin metal organic framework (γ-CD-MOF) does not meet the requirements for targeted drug delivery applications. Herein, we synthesized γ-CD-MOF and crosslinked γ-CD-MOF (CL-γ-CD-MOF) to obtain the different sizes and different types of γ-CD-MOF. Furthermore, a simple post-modification method was applied to obtain the biofunctionalized γ-CD-MOFs to improve cellular interaction through hyaluronic acid (HA) for the first time. Various methods including measurement of different size of γ-CD-MOF, CL-γ-CD-MOF, and surface modified γ-CD-MOFs, followed by the characterization by various analytical techniques, drug absorption, cell viability, and cellular uptake studies, were performed to determine the functionality of the studied γ-CD-MOF-HA systems. The conjugation of γ-CD-MOF with HA (γ-CD-MOF-HA) showed a 4.8% higher average drug loading capacity than the γ-CD-MOF. It was found that the γ-CD-MOF-HA showed pH-responsive drug release and enhanced the cellular uptake of Doxorubicin (Dox) in HeLa cells. The present study results indicate the efficacy of the γ-CD-MOF-HA as a nano carrier, enabling a new direction for γ-CD-MOF to target the different tissues and cells. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | Corresponding
|
Funding Project | Shenzhen Polytechnic[6019330006K];Shenzhen Polytechnic[6019330007K];
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WOS Research Area | Materials Science
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WOS Subject | Materials Science, Multidisciplinary
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WOS Accession No | WOS:000839349900003
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Publisher | |
EI Accession Number | 20223012393203
|
EI Keywords | Controlled drug delivery
; Hyaluronic acid
; Lanthanum compounds
; Metal-Organic Frameworks
; Metals
; Organic acids
; Targeted drug delivery
|
ESI Classification Code | Metallurgy:531.1
; Organic Compounds:804.1
|
ESI Research Field | MATERIALS SCIENCE
|
Scopus EID | 2-s2.0-85134425078
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Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:1
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/359532 |
Department | School of Medicine |
Affiliation | 1.Postdoctoral Innovation Practice Base,Shenzhen Polytechnic,Shenzhen,518055,China 2.Department of Molecular and Cell Biology,University of Connecticut,United States 3.Department of Chemistry,University of Connecticut,United States 4.School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China 5.Department of Mechanical Engineering,University of Connecticut,United States |
Corresponding Author Affilication | School of Medicine |
Recommended Citation GB/T 7714 |
Singh,Parbeen,Feng,Jinglong,Golla,Vinaya Kumar,et al. Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,289.
|
APA |
Singh,Parbeen,Feng,Jinglong,Golla,Vinaya Kumar,Lotfi,Ali,&Tyagi,Deependra.(2022).Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency.MATERIALS CHEMISTRY AND PHYSICS,289.
|
MLA |
Singh,Parbeen,et al."Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency".MATERIALS CHEMISTRY AND PHYSICS 289(2022).
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