Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency

Singh，Parbeen1,5; Feng，Jinglong1; Golla，Vinaya Kumar2; Lotfi，Ali3; Tyagi，Deependra4

2022-09-15

10.1016/j.matchemphys.2022.126496

MATERIALS CHEMISTRY AND PHYSICS   Impact Factor & Quartile

0254-0584

1879-3312

The off-target payload delivery of γ-cyclodextrin metal organic framework (γ-CD-MOF) does not meet the requirements for targeted drug delivery applications. Herein, we synthesized γ-CD-MOF and crosslinked γ-CD-MOF (CL-γ-CD-MOF) to obtain the different sizes and different types of γ-CD-MOF. Furthermore, a simple post-modification method was applied to obtain the biofunctionalized γ-CD-MOFs to improve cellular interaction through hyaluronic acid (HA) for the first time. Various methods including measurement of different size of γ-CD-MOF, CL-γ-CD-MOF, and surface modified γ-CD-MOFs, followed by the characterization by various analytical techniques, drug absorption, cell viability, and cellular uptake studies, were performed to determine the functionality of the studied γ-CD-MOF-HA systems. The conjugation of γ-CD-MOF with HA (γ-CD-MOF-HA) showed a 4.8% higher average drug loading capacity than the γ-CD-MOF. It was found that the γ-CD-MOF-HA showed pH-responsive drug release and enhanced the cellular uptake of Doxorubicin (Dox) in HeLa cells. The present study results indicate the efficacy of the γ-CD-MOF-HA as a nano carrier, enabling a new direction for γ-CD-MOF to target the different tissues and cells.

Biofunctionalization Crosslinked γ-CD-MOF Hyaluronic acid Metal organic framework Targeted drug delivery

SCI ; EI

English

Corresponding

Shenzhen Polytechnic[6019330006K];Shenzhen Polytechnic[6019330007K];

Materials Science

Materials Science, Multidisciplinary

WOS:000839349900003

ELSEVIER SCIENCE SA

20223012393203

Controlled drug delivery ; Hyaluronic acid ; Lanthanum compounds ; Metal-Organic Frameworks ; Metals ; Organic acids ; Targeted drug delivery

Metallurgy:531.1 ; Organic Compounds:804.1

MATERIALS SCIENCE

2-s2.0-85134425078

Scopus

1.Postdoctoral Innovation Practice Base,Shenzhen Polytechnic,Shenzhen,518055,China
2.Department of Molecular and Cell Biology,University of Connecticut,United States
3.Department of Chemistry,University of Connecticut,United States
4.School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China
5.Department of Mechanical Engineering,University of Connecticut,United States

Singh，Parbeen,Feng，Jinglong,Golla，Vinaya Kumar,et al. Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,289.

Singh，Parbeen,Feng，Jinglong,Golla，Vinaya Kumar,Lotfi，Ali,&Tyagi，Deependra.(2022).Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency.MATERIALS CHEMISTRY AND PHYSICS,289.

Singh，Parbeen,et al."Crosslinked and biofunctionalized γ-cyclodextrin metal organic framework to enhance cellular binding efficiency".MATERIALS CHEMISTRY AND PHYSICS 289(2022).