Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples

Yu，Siyang1,2; Zhang，Peiyan3; Liao，Mingfeng1; Zhang，Juanjuan1; Luo，Suisui4; Zhai，Jinglei4; Zhang，Yaxi1; Lin，Jingyan1; Yuan，Jing3; Zhang，Zheng1,5; Wang，Fuxiang3; Wei，Lanlan1

2022-07-08

10.3389/fimmu.2022.880154

Frontiers in Immunology   Impact Factor & Quartile

1664-3224

1664-3224

Molecular assays on nasopharyngeal swabs act as a confirmatory test in coronavirus disease (COVID-19) diagnosis. However, the technical requirements of nasopharyngeal sampling and molecular assays limit the testing capabilities. Recent studies suggest the use of saliva for the COVID-19 diagnostic test. In this study, 44 patients diagnosed with COVID-19 in The Third People’s Hospital of Shenzhen were enrolled. Saliva and serum specimens were obtained at different time points and the immunoglobulins against SARS-CoV-2 were measured. The results showed that saliva IgA presented a higher COI value than IgG and IgM. In matched saliva and serum samples, all saliva samples presented lower IgG levels than serum samples, and only one saliva sample presented a higher IgM level. The conversion rates of saliva IgA and the detection of viral nucleic acids were analyzed in the first and second weeks after hospitalization. The positive rates increased when combining saliva IgA and viral nucleic acid detection. In conclusion, our results provide evidence that saliva IgA could serve as a useful index for the early diagnosis of COVID-19.

COVID-19 diagnose immunoglobulins saliva IgA SARS-CoV-2

SCI

English

Others

[SZGSP010] ; [SZGSP011]

Immunology

Immunology

WOS:000890909000001

FRONTIERS MEDIA SA

2-s2.0-85134712234

Scopus

1.Institute of Hepatology,National Clinical Research Center for Infectious Disease,The Third People’s Hospital of Shenzhen,The Second Hospital Affiliated to Southern,University of Science and Technology,Shenzhen,China
2.Clinical Laboratory,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,China
3.Department of Infectious Diseases,The Third People’s Hospital of Shenzhen,The Second Hospital Affiliated to Southern,University of Science and Technology,Shenzhen,China
4.School of Medicine,Southern University of Science and Technology,Shenzhen,China
5.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,China

Yu，Siyang,Zhang，Peiyan,Liao，Mingfeng,et al. Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples[J]. Frontiers in Immunology,2022,13.

Yu，Siyang.,Zhang，Peiyan.,Liao，Mingfeng.,Zhang，Juanjuan.,Luo，Suisui.,...&Wei，Lanlan.(2022).Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples.Frontiers in Immunology,13.

Yu，Siyang,et al."Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples".Frontiers in Immunology 13(2022).