Therapeutic effect of ketogenic diet treatment on type 2 diabetes

Li，Fang1; Shen，Yang2; Chen，Qun1; Li，Xingyu1; Yang，Hongnan3; Zhang，Canyang1; Lin，Jinjun2; Du，Zhicheng1; Jiang，Chenyao1; Yang，Chengming4; Yu，Dongmei5; Qin，Peiwu1

2022-06-01

10.1016/j.jfutfo.2022.03.004

Journal of Future Foods   Impact Factor & Quartile

2772-5669

Diet plays an important role in diabetes development. The effect of ketogenic diet on type 2 diabetes remains elusive. In this study, we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment. Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c (HbA1c) concentration, Triglyceride (TG), Fasting blood glucose (FBG), Body Mass Index (BMI), and adipose tissue volume. Moreover, we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test (SOOGTT) incorporate more sampling points by fitting OGTT (Oral Glucose Tolerance Test) curve. SOOGTT shows statistically significant (P < 0.001) treating effect of ketogenic diet on type 2 diabetes. We use artificial intelligence to segment adipose tissue for treatment evaluation, which shows that ketogenic diet reduces the amount of adipose tissue.

Diabetic physiological parameters Ketogenic diet MRI images Offset of Oral Glucose Tolerance Test (SOOGTT) Type 2 diabetes

English

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2-s2.0-85134576299

Scopus

1.Institute of Bio-pharmaceutical and Health Engineering,Tsinghua Shenzhen International Graduate School,Shenzhen,518101,China
2.Department of Endocrinology,Baoan Central Hospital of Shenzhen,the Fifth Affiliated Hospital of Shenzhen University,Shenzhen,518055,China
3.Department of Automation,Hangzhou Dianzi University,Hangzhou,310016,China
4.Southern University of Science and Technology Hospital,Shenzhen,518055,China
5.Department of Electromechanical and Information Engineering,Shandong University,Weihai,264209,China

Li，Fang,Shen，Yang,Chen，Qun,et al. Therapeutic effect of ketogenic diet treatment on type 2 diabetes[J]. Journal of Future Foods,2022,2(2):177-183.

Li，Fang.,Shen，Yang.,Chen，Qun.,Li，Xingyu.,Yang，Hongnan.,...&Qin，Peiwu.(2022).Therapeutic effect of ketogenic diet treatment on type 2 diabetes.Journal of Future Foods,2(2),177-183.

Li，Fang,et al."Therapeutic effect of ketogenic diet treatment on type 2 diabetes".Journal of Future Foods 2.2(2022):177-183.