中文版 | English
Title

Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2

Author
Corresponding AuthorMa,Baode; Zhang,Xumu
Publication Years
2022-06-24
DOI
Source Title
EISSN
2666-5549
Volume3Issue:3
Abstract

A highly efficient and enantioselective method for the asymmetric reductive amination of β-keto phosphine derivatives was disclosed, and the corresponding β-amino phosphine oxides could be obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 97% ee). Moreover, the reaction worked well on a gram scale, indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.

Keywords
URL[Source Record]
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Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Natural Science Foundation of China[21901107] ; National Natural Science Foundation of China["21901107","2020B010188001","2022B1515020055"] ; Shenzhen Bay Laboratory[22171129] ; Shenzhen Science and Technology Innovation Committee["22001113","2020KCXTD016"] ; Key-Area Research and Development Program of Guangdong Province[SZBL2019062801006] ; Stable Support Plan Program of Shenzhen Science and Technology Innovation Committee[KQTD20150717103157174] ; Innovative Team of Universities in Guangdong Province[JCYJ20210324104202007] ; Guangdong Basic and Applied Basic Research Foundation[20200925161222002]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:001025341600001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/359574
DepartmentDepartment of Chemistry
前沿与交叉科学研究院
Affiliation
1.Medi-X Pingshan,Guangdong Provincial Key Laboratory of Catalysis,and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518000,China
2.Shenzhen Bay Laboratory,Shenzhen,518132,China
3.Academy for Advanced Interdisciplinary Studies and Southern University of Science and Technology,Shenzhen,518000,China
First Author AffilicationDepartment of Chemistry
Corresponding Author AffilicationDepartment of Chemistry
First Author's First AffilicationDepartment of Chemistry
Recommended Citation
GB/T 7714
Liu,Yufeng,Wang,Linzhou,Li,Yingjun,et al. Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2[J]. Green Synthesis and Catalysis,2022,3(3).
APA
Liu,Yufeng,Wang,Linzhou,Li,Yingjun,Ma,Baode,Chen,Gen Qiang,&Zhang,Xumu.(2022).Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2.Green Synthesis and Catalysis,3(3).
MLA
Liu,Yufeng,et al."Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2".Green Synthesis and Catalysis 3.3(2022).
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