中文版 | English
Title

Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

Author
Corresponding AuthorXu,Gang
Publication Years
2022
DOI
Source Title
ISSN
0163-4453
EISSN
1532-2742
Abstract
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patients. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS.
Keywords
URL[Source Record]
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Natural Science Foundation of Guangdong Province[2019A1515011072];National Key Research and Development Program of China[2021YFC2300103];National Science Fund for Distinguished Young Scholars[82025022];National Natural Science Foundation of China[82151212];
ESI Research Field
IMMUNOLOGY
Scopus EID
2-s2.0-85134557803
Data Source
Scopus
Citation statistics
Cited Times [WOS]:8
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/359588
DepartmentSchool of Medicine
南方科技大学第二附属医院
Affiliation
1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518112,China
2.Department for Pathology,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China
3.Guangzhou Laboratory,Guangzhou Medical University,Guangzhou,China
4.Guangdong Key laboratory for anti-infection Drug Quality Evaluation,Shenzhen,Guangdong,518112,China
5.Shenzhen Research Center for Communicable Disease Diagnosis,Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong,518112,China
First Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Corresponding Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
First Author's First AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Recommended Citation
GB/T 7714
Gao,Xiang,Zhang,Shengyuan,Gou,Jizhou,et al. Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection[J]. JOURNAL OF INFECTION,2022.
APA
Gao,Xiang.,Zhang,Shengyuan.,Gou,Jizhou.,Wen,Yanling.,Fan,Lujie.,...&Zhang,Zheng.(2022).Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection.JOURNAL OF INFECTION.
MLA
Gao,Xiang,et al."Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection".JOURNAL OF INFECTION (2022).
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