| Title | Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection |
| Author | |
| Corresponding Author | Xu，Gang |
| Publication Years | 2022
|
| DOI | |
| Source Title | |
| ISSN | 0163-4453
|
| EISSN | 1532-2742
|
| Abstract | The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patients. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS. |
| Keywords | |
| URL | [Source Record] |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Natural Science Foundation of Guangdong Province[2019A1515011072];National Key Research and Development Program of China[2021YFC2300103];National Science Fund for Distinguished Young Scholars[82025022];National Natural Science Foundation of China[82151212];
|
| ESI Research Field | IMMUNOLOGY
|
| Scopus EID | 2-s2.0-85134557803
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:8
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/359588 |
| Department | School of Medicine 南方科技大学第二附属医院 |
| Affiliation | 1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518112,China 2.Department for Pathology,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China 3.Guangzhou Laboratory,Guangzhou Medical University,Guangzhou,China 4.Guangdong Key laboratory for anti-infection Drug Quality Evaluation,Shenzhen,Guangdong,518112,China 5.Shenzhen Research Center for Communicable Disease Diagnosis,Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong,518112,China |
| First Author Affilication | School of Medicine; The Third People's Hospital of Shenzhen |
| Corresponding Author Affilication | School of Medicine; The Third People's Hospital of Shenzhen |
| First Author's First Affilication | School of Medicine; The Third People's Hospital of Shenzhen |
| Recommended Citation GB/T 7714 |
Gao，Xiang,Zhang，Shengyuan,Gou，Jizhou,et al. Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection[J]. JOURNAL OF INFECTION,2022.
|
| APA |
Gao，Xiang.,Zhang，Shengyuan.,Gou，Jizhou.,Wen，Yanling.,Fan，Lujie.,...&Zhang，Zheng.(2022).Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection.JOURNAL OF INFECTION.
|
| MLA |
Gao，Xiang,et al."Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection".JOURNAL OF INFECTION (2022).
|
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