Sugar-Sweeten Beverage Consumption Is Associated With More Obesity and Higher Serum Uric Acid in Chinese Male Gout Patients With Early Onset

Li, Qian-Hua1; Zou, Yao-Wei1; Lian, Shu-Yan2; Liang, Jin-Jian1; Bi, Yu-Fei3; Deng, Chao4; Mo, Ying-Qian1; Yang, Kui-Min1; Dai, Lie1

2022-07-12

10.3389/fnut.2022.916811

Frontiers in Nutrition   Impact Factor & Quartile

2296-861X

BackgroundEarly onset gout has received increasing interest from researchers. Previous studies have reported that serum urate (sUA) levels and prevalence of obesity are higher in early onset gout patients than in later-onset gout patients. We explored the dietary habits of early onset and later-onset gout patients and their association with clinical features. Materials and MethodsGout patients completed a 10-item food frequency questionnaire. Early onset gout patients were defined as gout onset before the age of 40, and onset after age 40 was classified as later-onset. Associations between dietary factors, obesity, and sUA level of >= 600 mu mol/L were assessed using logistic regression. ResultsAmong the 655 gout patients, 94.6% were males, and 59.1% presented with early onset gout. All early onset patients were males. sUA level was significantly higher in the early onset group than in the later-onset group (550.7 vs. 513.4 mu mol/L). The proportion of patients with a sUA level of >= 600 mu mol/L (40.3 vs. 26.2%) and obesity (27.6 vs. 10.7%) was higher in the early onset group than in the later-onset group (all p < 0.05). The early onset group consumed more red meat (101-200 g/day: 43.6 vs. 26.0%), sugar-sweetened beverages (>4 times/week: 27.9 vs. 7.7%), and milk and milk products (1-2 times/week: 28.5 vs. 16.6%), but less alcohol (>84 g/day: 8.5 vs. 21.5%) and tea (>4 times/week: 35.7 vs. 52.4%; all p < 0.05). Sugar-sweetened beverage intake was positively correlated with sUA level of >= 600 mu mol/L (compared with 4 times/week: adjusted odds ratio = 2.2, 95% confidence interval: 1.4, 3.7) and obesity (compared with 4 times/week: adjusted odds ratio = 2.2, 95% confidence interval: 1.2, 3.7). These correlations remained significant for early onset gout patients. ConclusionSugar-sweetened beverage intake replaced alcohol as the main dietary risk factor for gout in early onset patients, and this change was associated with a greater prevalence of obesity and higher sUA level. Clinicians should provide specific dietary education for different generations of gout patients. The epidemic of sugar-sweetened beverage consumption should be considered for the development of public health policies for the prevention of gout.

early onset gout food frequency questionnaire sugar-sweeten beverages obesity serum urate

SCI

English

Others

Nutrition & Dietetics

Nutrition & Dietetics

WOS:000833943900001

FRONTIERS MEDIA SA

Web of Science

1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Rheumatol, Guangzhou, Peoples R China
2.Sun Yat Sen Univ, Mem Hosp, Shenshan Med Ctr, Dept Rheumatol, Shanwei, Peoples R China
3.Shandong Univ, Qilu Hosp, Dept Rheumatol, Qingdao, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Rheumatol, Shenzhen, Peoples R China

Li, Qian-Hua,Zou, Yao-Wei,Lian, Shu-Yan,et al. Sugar-Sweeten Beverage Consumption Is Associated With More Obesity and Higher Serum Uric Acid in Chinese Male Gout Patients With Early Onset[J]. Frontiers in Nutrition,2022,9.

Li, Qian-Hua.,Zou, Yao-Wei.,Lian, Shu-Yan.,Liang, Jin-Jian.,Bi, Yu-Fei.,...&Dai, Lie.(2022).Sugar-Sweeten Beverage Consumption Is Associated With More Obesity and Higher Serum Uric Acid in Chinese Male Gout Patients With Early Onset.Frontiers in Nutrition,9.

Li, Qian-Hua,et al."Sugar-Sweeten Beverage Consumption Is Associated With More Obesity and Higher Serum Uric Acid in Chinese Male Gout Patients With Early Onset".Frontiers in Nutrition 9(2022).